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Comprehensive molecular characterization of gastric adenocarcinoma

Authors
 Cancer Genome Atlas Research Network 
Citation
 NATURE, Vol.513(7517) : 202-209, 2014 
Journal Title
NATURE
ISSN
 0028-0836 
Issue Date
2014
MeSH
Adenocarcinoma/classification* ; Adenocarcinoma/genetics* ; Adenocarcinoma/virology ; Female ; Gene Expression Regulation, Neoplastic ; Genome, Human/genetics* ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/isolation & purification ; Humans ; Male ; Mutation ; Proteome ; Stomach Neoplasms/classification* ; Stomach Neoplasms/genetics* ; Stomach Neoplasms/virology
Abstract
Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein-Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies.
Files in This Item:
T201406278.pdf Download
DOI
10.1038/nature13480
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158586
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