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Rosai-Dorfman Disease in Thoracic Spine : A Rare Case of Compression Fracture

Authors
 Do Young Kim  ;  Ji Hye Park  ;  Dong Ah Shin  ;  Seung Yi  ;  Yoon Ha  ;  Do Heum Yoon  ;  Keung Nyun Kim 
Citation
 Korean Journal of Spine, Vol.11(3) : 198-201, 2014 
Journal Title
 Korean Journal of Spine 
ISSN
 1738-2262 
Issue Date
2014
Keywords
Rosai-Dorfman disease ; Extranodal involvement ; Thoracic vertebra ; Compression fracture
Abstract
Sinus histiocytosis with massive lymphadenopathy known as Rosai-Dorfman disease is characterized by painless bilateral cervicallymphadenopathy. Extranodal manifestations are uncommon and spinal involvement is rare. A 15-year-old man presented with intermittent midthoracic back pain only. He had no specific findings on neurologic examinations, hematologic and biochemical laboratory tests. Radiological examination of thoracic spine revealed collapse of T6 vertebrae with thoracic kyphosis and osteolytic lesion of T12 vertebra body. He underwent a removal of bone tumor, anterior reconstruction with mesh and pedicle screw fixation via posterior approach for pathologic confirmation and stabilization. Histopathologic study of the lesion revealed focal infiltration of large histiocytes showing emperipolesis. Immunochemistry stain of histiocytes was positive for CD68 and S-100 but negative for CD1a. This report presents a rare case and literature review of extranodal Rosai-dorfman disease in thoracic spine.
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DOI
10.14245/kjs.2014.11.3.198
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Keung Nyun(김긍년)
Kim, Do Young(김도영)
Park, Ji Hye(박지혜)
Shin, Dong Ah(신동아) ORCID logo https://orcid.org/0000-0002-5225-4083
Yoon, Do Heum(윤도흠) ORCID logo https://orcid.org/0000-0003-1452-5724
Yi, Seong(이성)
Ha, Yoon(하윤)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158575
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