Cited 32 times in
Inhalation of carbon black nanoparticles aggravates pulmonary inflammation in mice
DC Field | Value | Language |
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dc.contributor.author | 윤진하 | - |
dc.date.accessioned | 2018-05-10T06:45:06Z | - |
dc.date.available | 2018-05-10T06:45:06Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1976-8257 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/158564 | - |
dc.description.abstract | An increasing number of recent studies have focused on the impact of particulate matter on human health. As a model for atmospheric particulate inhalation, we investigated the effects of inhaled carbon black nanoparticles (CBNP) on mice with bleomycin-induced pulmonary fibrosis. The CNBPs were generated by a novel aerosolization process, and the mice were exposed to the aerosol for 4 hours. We found that CBNP inhalation exacerbated lung inflammation, as evidenced by histopathology analysis and by the expression levels of interleukin-6 protein, fibronectin, and interferon-γ mRNAs in lung tissues. Notably, fibronectin mRNA expression showed a statistically significant increase in expression after CBNP exposure. These data suggest that the concentration of CBNPs delivered (calculated to be 12.5 μg/m(3)) can aggravate lung inflammation in mice. Our results also suggest that the inhalation of ultrafine particles like PM 2.5 is an impactful environmental risk factor for humans, particularly in susceptible populations with predisposing lung conditions. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society of Toxicology | - |
dc.relation.isPartOf | TOXICOLOGICAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Inhalation of carbon black nanoparticles aggravates pulmonary inflammation in mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Preventive Medicine | - |
dc.contributor.googleauthor | Devina Saputra | - |
dc.contributor.googleauthor | Jin-ha Yoon | - |
dc.contributor.googleauthor | Hyunju Park | - |
dc.contributor.googleauthor | Yongju Heo | - |
dc.contributor.googleauthor | Hyoseon Yang | - |
dc.contributor.googleauthor | Eun Ji Lee | - |
dc.contributor.googleauthor | Sangjin Lee | - |
dc.contributor.googleauthor | Chang-Woo Song | - |
dc.contributor.googleauthor | Kyuhong Lee | - |
dc.identifier.doi | 10.5487/TR.2014.30.2.083 | - |
dc.contributor.localId | A04616 | - |
dc.relation.journalcode | J03278 | - |
dc.identifier.eissn | 2234-2753 | - |
dc.identifier.pmid | 25071917 | - |
dc.subject.keyword | Carbon black nanoparticles | - |
dc.subject.keyword | Inhalation toxicity | - |
dc.subject.keyword | Lung inflammation | - |
dc.subject.keyword | Ultrafine particle | - |
dc.contributor.alternativeName | Yoon, Jin Ha | - |
dc.contributor.affiliatedAuthor | Yoon, Jin Ha | - |
dc.citation.volume | 30 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 83 | - |
dc.citation.endPage | 90 | - |
dc.identifier.bibliographicCitation | TOXICOLOGICAL RESEARCH, Vol.30(2) : 83-90, 2014 | - |
dc.identifier.rimsid | 43149 | - |
dc.type.rims | ART | - |
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