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Extravasating Neutrophil-derived Microparticles Preserve Vascular Barrier Function in Inflamed Tissue

DC FieldValueLanguage
dc.contributor.author현영민-
dc.date.accessioned2018-05-10T06:43:10Z-
dc.date.available2018-05-10T06:43:10Z-
dc.date.issued2013-
dc.identifier.issn1598-2629-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/158501-
dc.description.abstractEmerging evidence suggests that gap formation and opening of the endothelial junctions during leukocyte extravasation is actively controlled to maintain the integrity of the vascular barrier. While the role for endothelial cells to this process has been well defined, it is not clear whether leukocytes are also actively contributing to endothelial barrier function. We have recently showed that extravasating leukocytes deposit microparticles on the subendothelium during the late stages of extravasation, which is LFA-1 dependent. Using multiphotonintravital microscopy (MP-IVM) of mouse cremaster muscle vessels in the current work, we show that microparticle formation and deposition maintains the integrity of the microvascular barrier during leukocyte extravasation. Inhibition of neutrophil-derived microparticle formation resulted in dramatically increased vascular leakage. These findings suggest that deposition of microparticles during neutrophil extravasation is essential for maintaining endothelial barrier function and may result in temporal difference between neutrophil extravasation and an increase in vascular leakage-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorea Society for Immunology : Korean Society of Biological Response Modifiers-
dc.relation.isPartOfImmune Network-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleExtravasating Neutrophil-derived Microparticles Preserve Vascular Barrier Function in Inflamed Tissue-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anatomy-
dc.contributor.googleauthorKihong Lim-
dc.contributor.googleauthorRonen Sumagin-
dc.contributor.googleauthorYoung-Min Hyun-
dc.identifier.doi10.4110/in.2013.13.3.102-
dc.contributor.localIdA04814-
dc.relation.journalcodeJ01033-
dc.identifier.eissn2092-6685-
dc.identifier.pmid23885224-
dc.subject.keywordLeukocyte extravasation-
dc.subject.keywordMicroparticles-
dc.subject.keywordMonocytes-
dc.subject.keywordNeutrophils-
dc.subject.keywordVascular barrier function-
dc.contributor.alternativeNameHyun, Young-Min-
dc.contributor.affiliatedAuthorHyun, Young-Min-
dc.citation.volume13-
dc.citation.number3-
dc.citation.startPage102-
dc.citation.endPage106-
dc.identifier.bibliographicCitationImmune Network, Vol.13(3) : 102-106, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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