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Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV

DC FieldValueLanguage
dc.contributor.author현영민-
dc.date.accessioned2018-05-10T06:43:09Z-
dc.date.available2018-05-10T06:43:09Z-
dc.date.issued2013-
dc.identifier.issn1529-2908-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/158500-
dc.description.abstractLeukocytes must traverse inflamed tissues to effectively control local infection. Although motility in dense tissues seems to be integrin independent and based on actomyosin-mediated protrusion and contraction, during inflammation, changes to the extracellular matrix (ECM) may necessitate distinct motility requirements. Indeed, we found that the interstitial motility of T cells was critically dependent on Arg-Gly-Asp (RGD)-binding integrins in the inflamed dermis. Inflammation-induced deposition of fibronectin was functionally linked to higher expression of integrin αV on effector CD4⁺ T cells. By intravital multiphoton imaging, we found that the motility of CD4⁺ T cells was dependent on αV expression. Selective blockade or knockdown of αV arrested T helper type 1 (TH1) cells in the inflamed tissue and attenuated local effector function. Our data demonstrate context-dependent specificity of lymphocyte movement in inflamed tissues that is essential for protective immunity.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature America Inc.-
dc.relation.isPartOfNATURE IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCD4-Positive T-Lymphocytes/immunology*-
dc.subject.MESHCD4-Positive T-Lymphocytes/metabolism*-
dc.subject.MESHCell Movement/immunology*-
dc.subject.MESHDermis/immunology-
dc.subject.MESHDermis/metabolism-
dc.subject.MESHExtracellular Matrix/metabolism-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHInflammation/genetics-
dc.subject.MESHInflammation/immunology*-
dc.subject.MESHInflammation/metabolism*-
dc.subject.MESHIntegrin alphaV/genetics-
dc.subject.MESHIntegrin alphaV/metabolism*-
dc.subject.MESHLymph Nodes/immunology-
dc.subject.MESHMice-
dc.subject.MESHOligopeptides/metabolism-
dc.subject.MESHProtein Binding-
dc.subject.MESHTh1 Cells/immunology-
dc.subject.MESHTh1 Cells/metabolism-
dc.titleInflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anatomy-
dc.contributor.googleauthorMichael G. Overstreet-
dc.contributor.googleauthorAlison Gaylo-
dc.contributor.googleauthorBastian Angermann-
dc.contributor.googleauthorAngela Hughson-
dc.contributor.googleauthorYoung-min Hyun-
dc.contributor.googleauthorKris Lambert-
dc.contributor.googleauthorMridu Acharya-
dc.contributor.googleauthorAlison C. Billroth-Maclurg-
dc.contributor.googleauthorAlexander F. Rosenberg-
dc.contributor.googleauthorDavid J. Topham-
dc.contributor.googleauthorHideo Yagita-
dc.contributor.googleauthorMinsoo Kim-
dc.contributor.googleauthorAdam Lacy-Hulbert-
dc.contributor.googleauthorMartin Meier-Schellersheim-
dc.contributor.googleauthorDeborah J. Fowell-
dc.identifier.doi10.1038/ni.2682-
dc.contributor.localIdA04814-
dc.relation.journalcodeJ03205-
dc.identifier.eissn1529-2916-
dc.identifier.pmid23933892-
dc.contributor.alternativeNameHyun, Young-Min-
dc.contributor.affiliatedAuthorHyun, Young-Min-
dc.citation.volume14-
dc.citation.number9-
dc.citation.startPage949-
dc.citation.endPage958-
dc.identifier.bibliographicCitationNATURE IMMUNOLOGY, Vol.14(9) : 949-958, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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