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Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV

Authors
 Michael G. Overstreet  ;  Alison Gaylo  ;  Bastian Angermann  ;  Angela Hughson  ;  Young-min Hyun  ;  Kris Lambert  ;  Mridu Acharya  ;  Alison C. Billroth-Maclurg  ;  Alexander F. Rosenberg  ;  David J. Topham  ;  Hideo Yagita  ;  Minsoo Kim  ;  Adam Lacy-Hulbert  ;  Martin Meier-Schellersheim  ;  Deborah J. Fowell 
Citation
 Nature Immunology, Vol.14(9) : 949-958, 2013 
Journal Title
 Nature Immunology 
ISSN
 1529-2908 
Issue Date
2013
MeSH
Animals ; CD4-Positive T-Lymphocytes/immunology* ; CD4-Positive T-Lymphocytes/metabolism* ; Cell Movement/immunology* ; Dermis/immunology ; Dermis/metabolism ; Extracellular Matrix/metabolism ; Gene Expression Regulation ; Inflammation/genetics ; Inflammation/immunology* ; Inflammation/metabolism* ; Integrin alphaV/genetics ; Integrin alphaV/metabolism* ; Lymph Nodes/immunology ; Mice ; Oligopeptides/metabolism ; Protein Binding ; Th1 Cells/immunology ; Th1 Cells/metabolism
Abstract
Leukocytes must traverse inflamed tissues to effectively control local infection. Although motility in dense tissues seems to be integrin independent and based on actomyosin-mediated protrusion and contraction, during inflammation, changes to the extracellular matrix (ECM) may necessitate distinct motility requirements. Indeed, we found that the interstitial motility of T cells was critically dependent on Arg-Gly-Asp (RGD)-binding integrins in the inflamed dermis. Inflammation-induced deposition of fibronectin was functionally linked to higher expression of integrin αV on effector CD4⁺ T cells. By intravital multiphoton imaging, we found that the motility of CD4⁺ T cells was dependent on αV expression. Selective blockade or knockdown of αV arrested T helper type 1 (TH1) cells in the inflamed tissue and attenuated local effector function. Our data demonstrate context-dependent specificity of lymphocyte movement in inflamed tissues that is essential for protective immunity.
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DOI
10.1038/ni.2682
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Hyun, Young-Min(현영민) ORCID logo https://orcid.org/0000-0002-0567-2039
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158500
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