Cited 17 times in
House dust mite allergen Der f 2 induces interleukin-13 expression by activating the PI3K/Akt pathway
DC Field | Value | Language |
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dc.contributor.author | 박중원 | - |
dc.date.accessioned | 2018-05-10T06:43:05Z | - |
dc.date.available | 2018-05-10T06:43:05Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0257-277X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/158496 | - |
dc.description.abstract | House dust mites (HDMs) are a common cause of allergic asthma. The group 2 allergen from Dermatophagoides farinae, Der f 2, is one of the major HDM allergens. Elevated Der f 2 immunoglobulin E (IgE) levels are observed in most of the allergic patients. Interleukin-13 (IL-13), a gene associated with asthma pathology, was induced by Der f 2 in BEAS-2B human airway epithelial cells; however, the signaling pathways associated with Der f 2 are not fully understood. In this study, we identified a role of the phosphatidylinositol-3-kinase (PI3K)/Akt pathway, a well-known potential target for anti-asthma drugs, in the IL-13 induction by Der f 2. First, Der f 2 activated the PI3K/Akt pathway, which subsequently activated the nuclear factor-kappa B (NF-κB) pathway and induced IL-13 expression in BEAS-2B cells. Treatment with the PI3K inhibitor LY294002 abolished Der f 2-induced activation of Akt and NF-κB and the expression of IL-13. Furthermore, Der f 2-induced activation of the PI3K/Akt and NF-κB pathways, expression of IL-13, and the blockade of these effects with a PI3K inhibitor were confirmed in the lungs of mice that were intranasally exposed to Der f 2. Taken together, these results indicate that the PI3K/Akt pathway regulates Der f 2-induced IL-13 expression via activation of the NF-κB pathway. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | United States | - |
dc.publisher | 1559-0755 | - |
dc.relation.isPartOf | IMMUNOLOGIC RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antigens, Dermatophagoides/immunology* | - |
dc.subject.MESH | Arthropod Proteins/immunology* | - |
dc.subject.MESH | Asthma/immunology* | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Gene Expression Regulation/immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin E/blood | - |
dc.subject.MESH | Interleukin-13/genetics | - |
dc.subject.MESH | Interleukin-13/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | NF-kappa B/metabolism | - |
dc.subject.MESH | Oncogene Protein v-akt/metabolism | - |
dc.subject.MESH | Phosphatidylinositol 3-Kinases/metabolism* | - |
dc.subject.MESH | Pyroglyphidae/immunology | - |
dc.subject.MESH | Respiratory Mucosa/immunology* | - |
dc.subject.MESH | Signal Transduction/immunology | - |
dc.subject.MESH | Transcriptional Activation/immunology | - |
dc.title | House dust mite allergen Der f 2 induces interleukin-13 expression by activating the PI3K/Akt pathway | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Eun Ji Ro | - |
dc.contributor.googleauthor | Pu-Hyeon Cha | - |
dc.contributor.googleauthor | Hyun-Yi Kim | - |
dc.contributor.googleauthor | Yong-Hee Cho | - |
dc.contributor.googleauthor | Jung-Won Park | - |
dc.contributor.googleauthor | Joong-Soo Han | - |
dc.contributor.googleauthor | Kang-Yell Choi | - |
dc.identifier.doi | 10.1007/s12026-013-8392-0 | - |
dc.contributor.localId | A01681 | - |
dc.relation.journalcode | J03292 | - |
dc.identifier.eissn | 1559-0755 | - |
dc.identifier.pmid | 23564227 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12026-013-8392-0 | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.citation.volume | 56 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 181 | - |
dc.citation.endPage | 188 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGIC RESEARCH, Vol.56(1) : 181-188, 2013 | - |
dc.identifier.rimsid | 43099 | - |
dc.type.rims | ART | - |
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