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Short-term efficacy and tolerability of rufinamide adjunctive therapy in children with refractory generalised epilepsy

Authors
 Se Hee Kim  ;  Jeong Ho Lee  ;  Hye Won Ryu  ;  Byung Chan Lim  ;  Jong Hee Chae  ;  Ji Eun Choi  ;  Yong Seoung Hwang  ;  Ki Joong Kim 
Citation
 Epileptic Disorders, Vol.15(1) : 49-54, 2013 
Journal Title
 Epileptic Disorders 
ISSN
 1294-9361 
Issue Date
2013
MeSH
Adolescent ; Anticonvulsants/therapeutic use ; Child ; Child, Preschool ; Epilepsies, Myoclonic/drug therapy ; Epilepsy, Generalized/drug therapy ; Female ; Humans ; Intellectual Disability/drug therapy ; Lennox Gastaut Syndrome ; Male ; Spasms, Infantile/drug therapy ; Treatment Outcome ; Triazoles/therapeutic use
Keywords
anticonvulsant ; children ; generalized epilepsy ; rufinamide
Abstract
We evaluated the efficacy and tolerability of rufinamide adjunctive therapy in children with refractory generalised epilepsy. The study cohort consisted of 20 patients with Lennox-Gastaut syndrome, 5 with Dravet syndrome, and 28 with unclassified refractory generalised epilepsy. Patients with more than 50% seizure reduction at three and six months were defined as responders. The overall response rate was 37.7% at three months and 34.0% at six months. At three months, patients with Lennox-Gastaut syndrome (40.0%) and epilepsy with spasms/tonic seizures (38.5%) showed higher response rates than those with Dravet syndrome (20.0%) and epilepsy with myoclonic seizures (20.0%). High response rates in patients with Lennox-Gastaut syndrome (30.0%) and epilepsy with spasms/tonic seizures (38.5%) were sustained throughout the six-month study. The accuracy of, and differences between, responder rates should, however, be interpreted with caution due to the small number of patients. Overall, rufinamide appeared to be effective and reasonably well tolerated in this group of children with refractory generalised epilepsies, although a subgroup of patients with Dravet syndrome and epilepsy with myoclonic seizures were less responsive to rufinamide treatment.
Files in This Item:
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DOI
10.1684/epd.2013.0557
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hee(김세희) ORCID logo https://orcid.org/0000-0001-7773-1942
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158480
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