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NAD(P)H: quinone oxidoreductase 1 and NRH:quinone oxidoreductase 2 polymorphisms in papillary thyroid microcarcinoma: correlation with phenotype

 Junguee Lee  ;  Koon Soon Kim  ;  Min Ho Lee  ;  Yeon Soo Kim  ;  Min Hee Lee  ;  Seong Eun Lee  ;  Yong Kyung Kim  ;  Min Jeong Ryu  ;  Soung Jung Kim  ;  Min Jeong Choi  ;  Young Suk Jo 
 YONSEI MEDICAL JOURNAL, Vol.54(5) : 1158-1167, 2013 
Journal Title
Issue Date
Adult ; Carcinoma, Papillary/genetics* ; Carcinoma, Papillary/pathology ; DNA Mutational Analysis ; Female ; Genetic Predisposition to Disease ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Multivariate Analysis ; Mutagenesis, Insertional ; Mutation, Missense ; NAD(P)H Dehydrogenase (Quinone)/chemistry ; NAD(P)H Dehydrogenase (Quinone)/genetics* ; Phenotype ; Polymorphism, Genetic ; Prognosis ; Promoter Regions, Genetic ; Retrospective Studies ; Sequence Analysis, Protein ; Sequence Deletion ; Thyroid Neoplasms/genetics* ; Thyroid Neoplasms/pathology
NAD(P)H:Quinone Oxidoreductase 1 ; NRH:Quinone Oxidoreductase 2 ; thyroid neoplasm
PURPOSE: NAD(P)H:Quinone Oxidoreductase 1 (NQO1) C609T missense variant (NQO1*2) and 29 basepair (bp)-insertion/deletion (I29/D) polymorphism of the NRH:Quinone Oxidoreductase 2 (NQO2) gene promoter have been proposed as predictive and prognostic factors for cancer development and progression. The purpose of this study is to investigate the relationship between NQO1/NQO2 genotype and clinico-pathological features of papillary thyroid microcarcinoma (PTMC). MATERIALS AND METHODS: Genomic DNA was isolated from 243 patients; and clinical data were retrospectively analyzed. NQO1*2 and tri-allelic polymorphism of NQO2 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. RESULTS: PTMC with NQO1*2 frequently exhibited extra-thyroidal extension as compared to PTMC with wild-type NQO1 (p=0.039). There was a significant relationship between I29/I29 homozygosity of NQO2 and lymph node metastasis (p=0.042). Multivariate analysis showed that the I29/I29 genotype was associated with an increased risk of lymph node metastasis (OR, 2.24; 95% CI, 1.10-4.56; p=0.026). CONCLUSION: NQO1*2 and I29 allele of the NQO2 are associated with aggressive clinical phenotypes of PTMC, and the I29 allele represents a putative prognostic marker for PTMC.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jo, Young Suk(조영석) ORCID logo https://orcid.org/0000-0001-9926-8389
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