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Cardiovascular repair with bone marrow-derived cells

Authors
 Woan-Sang Kim  ;  Sangho Lee  ;  Young-sup Yoon 
Citation
 Blood Research, Vol.48(2) : 76-86, 2013 
Journal Title
 Blood Research 
ISSN
 2287-979X 
Issue Date
2013
Abstract
While bone marrow (BM)-derived cells have been comprehensively studied for their propitious pre-clinical results, clinical trials have shown controversial outcomes. Unlike previously acknowledged, more recent studies have now confirmed that humoral and paracrine effects are the key mechanisms for tissue regeneration and functional recovery, instead of transdifferentiation of BM-derived cells into cardiovascular tissues. The progression of the understanding of BM-derived cells has further led to exploring efficient methods to isolate and obtain, without mobilization, sufficient number of cell populations that would eventually have a higher therapeutic potential. As such, hematopoietic CD31(+) cells, prevalent in both bone marrow and peripheral blood, have been discovered, in recent studies, to have angiogenic and vasculogenic activities and to show strong potential for therapeutic neovascularization in ischemic tissues. This article will discuss recent advancement on BM-derived cell therapy and the implication of newly discovered CD31(+) cells.
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DOI
10.5045/br.2013.48.2.76
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
윤영섭(Yoon, Young Sup)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158452
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