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Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells

Authors
 Ji Woong Han  ;  Min Young Sin  ;  Young-sup Yoon 
Citation
 Diabetes & Metabolism Journal, Vol.37(2) : 91-105, 2013 
Journal Title
 Diabetes & Metabolism Journal 
ISSN
 2233-6079 
Issue Date
2013
Keywords
Diabetic neuropathies ; Stem cells ; Tissue therapy
Abstract
Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterized by reduction of vascularity in peripheral nerves and deficiency in neurotrophic and angiogenic factors. Previous studies have tried to introduce neurotrophic or angiogenic factors in the form of protein or gene for therapy, but the effect was not significant. Recent studies have shown that bone marrow (BM)-derived stem or progenitor cells have favorable effects on the repair of cardiovascular diseases. Since these BM-derived stem or progenitor cells contain various angiogenic and neurotrophic factors, these cells have been attempted for treating experimental DN, and turned out to be effective for reversing various manifestations of experimental DN. These evidences suggest that cell therapy, affecting both vascular and neural components, can represent a novel therapeutic option for treatment of clinical DN.
Files in This Item:
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DOI
10.4093/dmj.2013.37.2.91
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
윤영섭(Yoon, Young Sup)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158451
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