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Revisiting cardiovascular regeneration with bone marrow-derived angiogenic and vasculogenic cells

DC FieldValueLanguage
dc.contributor.author윤영섭-
dc.date.accessioned2018-05-10T06:41:49Z-
dc.date.available2018-05-10T06:41:49Z-
dc.date.issued2013-
dc.identifier.issn0007-1188-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/158450-
dc.description.abstractCell-based therapy has emerged as a promising therapy for cardiovascular disease. Particularly, bone marrow (BM)-derived cells have been most extensively investigated and have shown encouraging results in preclinical studies. Clinical trials, however, have demonstrated split results in post-myocardial infarction cardiac repair. Mechanistically, transdifferentiation of BM-derived cells into cardiovascular tissue demonstrated by earlier studies is now known to play a minor role in functional recovery, and humoral and paracrine effects turned out to be main mechanisms responsible for tissue regeneration and functional recovery. With this advancement in the mechanistic insight of BM-derived cells, new efforts have been made to identify cell population, which can be readily isolated and obtained in sufficient quantity without mobilization and have higher therapeutic potential. Recently, haematopoietic CD31(+) cells, which are more prevalent in bone marrow and peripheral blood, have been revealed to have angiogenic and vasculogenic activities and strong potential for therapeutic neovascularization in ischaemic tissues. This article will cover the recent advances in BM-derived cell-based therapy and implication of CD31(+) cells.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfBRITISH JOURNAL OF PHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBone Marrow Cells/cytology-
dc.subject.MESHBone Marrow Transplantation/methods-
dc.subject.MESHCardiovascular Diseases/physiopathology-
dc.subject.MESHCardiovascular Diseases/therapy-
dc.subject.MESHCell Transdifferentiation/physiology-
dc.subject.MESHCell- and Tissue-Based Therapy/methods-
dc.subject.MESHClinical Trials as Topic-
dc.subject.MESHHumans-
dc.subject.MESHNeovascularization, Physiologic-
dc.subject.MESHPlatelet Endothelial Cell Adhesion Molecule-1/metabolism-
dc.subject.MESHRegeneration/physiology-
dc.subject.MESHRegenerative Medicine/methods-
dc.titleRevisiting cardiovascular regeneration with bone marrow-derived angiogenic and vasculogenic cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorSangho Lee-
dc.contributor.googleauthorYoung-sup Yoon-
dc.identifier.doi10.1111/j.1476-5381.2012.01857.x-
dc.contributor.localIdA02579-
dc.relation.journalcodeJ00414-
dc.identifier.eissn1476-5381-
dc.identifier.pmid22250888-
dc.contributor.alternativeNameYoon, Young Sup-
dc.contributor.affiliatedAuthorYoon, Young Sup-
dc.citation.volume169-
dc.citation.number2-
dc.citation.startPage290-
dc.citation.endPage303-
dc.identifier.bibliographicCitationBRITISH JOURNAL OF PHARMACOLOGY, Vol.169(2) : 290-303, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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