71 64

Cited 13 times in

Revisiting cardiovascular regeneration with bone marrow-derived angiogenic and vasculogenic cells

Authors
 Sangho Lee  ;  Young-sup Yoon 
Citation
 British Journal of Pharmacology, Vol.169(2) : 290-303, 2013 
Journal Title
 British Journal of Pharmacology 
ISSN
 0007-1188 
Issue Date
2013
MeSH
Animals ; Bone Marrow Cells/cytology ; Bone Marrow Transplantation/methods ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/therapy ; Cell Transdifferentiation/physiology ; Cell- and Tissue-Based Therapy/methods ; Clinical Trials as Topic ; Humans ; Neovascularization, Physiologic ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Regeneration/physiology ; Regenerative Medicine/methods
Abstract
Cell-based therapy has emerged as a promising therapy for cardiovascular disease. Particularly, bone marrow (BM)-derived cells have been most extensively investigated and have shown encouraging results in preclinical studies. Clinical trials, however, have demonstrated split results in post-myocardial infarction cardiac repair. Mechanistically, transdifferentiation of BM-derived cells into cardiovascular tissue demonstrated by earlier studies is now known to play a minor role in functional recovery, and humoral and paracrine effects turned out to be main mechanisms responsible for tissue regeneration and functional recovery. With this advancement in the mechanistic insight of BM-derived cells, new efforts have been made to identify cell population, which can be readily isolated and obtained in sufficient quantity without mobilization and have higher therapeutic potential. Recently, haematopoietic CD31(+) cells, which are more prevalent in bone marrow and peripheral blood, have been revealed to have angiogenic and vasculogenic activities and strong potential for therapeutic neovascularization in ischaemic tissues. This article will cover the recent advances in BM-derived cell-based therapy and implication of CD31(+) cells.
Files in This Item:
T201306142.pdf Download
DOI
10.1111/j.1476-5381.2012.01857.x
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
윤영섭(Yoon, Young Sup)
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158450
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse