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Controlled delivery of low-dose bone morphogenetic protein-2 using heparin-conjugated fibrin in the posterolateral lumbar fusion of rabbits

 Ki-Hyoung Koo  ;  Jong-Min Lee  ;  Jung-Min Ahn  ;  Byung-Soo Kim  ;  Wan-Geun La  ;  Chang-Sung Kim  ;  Gun-Il Im 
 ARTIFICIAL ORGANS, Vol.37(5) : 487-494, 2013 
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Animals ; Biomechanical Phenomena ; Bone Morphogenetic Protein 2/administration & dosage ; Bone Morphogenetic Protein 2/chemistry ; Bone Regeneration/drug effects ; Delayed-Action Preparations ; Drug Carriers ; Fibrin/chemistry ; Heparin/chemistry ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/drug effects ; Lumbar Vertebrae/pathology ; Lumbar Vertebrae/surgery ; Male ; Palpation ; Rabbits ; Spinal Fusion ; Surgical Sponges ; Tensile Strength ; Time Factors ; Tomography, X-Ray Computed
The heparin-conjugated fibrin (HCF) system has been developed to deliver bone morphogenetic proteins (BMPs) for a long-term period and thus enhance bone regeneration. In the present study, we tested the effectiveness of the delivery system for spinal fusion with a very low dose of BMP-2. A total of 15 rabbits underwent posterolateral lumbar spine, divided into three groups. The control group received only collagen sponges without BMP-2, another group (BMP-only group) received collagen sponges loaded with BMP-2 (10 μg each side), and the last group (BMP/HCF group) received collagen sponges filled with HCF loaded with BMP-2 (10 μg each side). All animals were euthanized 8 weeks after surgery, and the fusion was assessed by radiographs, manual palpation, computed tomography scan, and mechanical testing. No case in the BMP/HCF group or in the control group achieved solid fusion, while all cases in BMP-only group showed evidence of solid fusion. BMP/HCF group had significantly lower fusion rate and tensile strength than BMP-only group at the dose of 10 μg of BMP-2. The HCF long-term delivery system with the low dose of BMP-2 (10 μg) is ineffective for the induction of lumbar posterolateral fusion in the rabbits.
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2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
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