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Epilepsy in Korean patients with Angelman syndrome

DC FieldValueLanguage
dc.contributor.author강훈철-
dc.contributor.author김흥동-
dc.contributor.author이영목-
dc.contributor.author이준수-
dc.date.accessioned2018-05-10T06:38:34Z-
dc.date.available2018-05-10T06:38:34Z-
dc.date.issued2012-
dc.identifier.issn1738-1061-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/158357-
dc.description.abstractPurpose : The aim of this study was to investigate the natural history of epilepsy and response to anti-epileptic drug treatment in patients with Angelman syndrome (AS) in Korea. Methods : We retrospectively reviewed the clinical records of 14 patients diagnosed with epilepsy out of a total of 17 patients with a genetic diagnosis of AS. These patients were seen at the Department of Pediatric Neurology at Severance Children's Hospital from March 2005 to March 2011. Results : Fourteen (9 males and 5 females) subjects (82.3%) were diagnosed with epilepsy in AS. The most common seizure types were generalized tonic-clonic (n=9, 27%) and myoclonic (n=9, 27%), followed by atonic (n=8, 24%), atypical absence (n=4, 12%) and complex partial seizure (n=3, 9%). The most commonly prescribed antiepileptic drug (AED) was valproic acid (VPA, n=12, 86%), followed by lamotrigine (LTG, n=9, 64%), and topiramate (n=8, 57%). According to questionnaires that determined whether each AED was efficacious or not, VPA had the highest response rate and LTG was associated with the highest rate of seizure exacerbation. Complete control of seizures was achieved in 6 patients. Partial control was achieved in 7 patients, while one patient was not controlled. Conclusion : Epilepsy is observed in the great majority of AS patients. It may have early onset and is often refractory to treatment. There are few reports about epilepsy in AS in Korea. This study will be helpful in understanding epilepsy in AS in Korea.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한소아과학회-
dc.relation.isPartOfKorean Journal of Pediatrics-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEpilepsy in Korean patients with Angelman syndrome-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorSung-Hee Park-
dc.contributor.googleauthorJung-Rim Yoon-
dc.contributor.googleauthorHeung Dong Kim-
dc.contributor.googleauthorJoon Soo Lee-
dc.contributor.googleauthorYoung-Mock Lee-
dc.contributor.googleauthorHoon-Chul Kang-
dc.identifier.doi10.3345/kjp.2012.55.5.171-
dc.contributor.localIdA00102-
dc.contributor.localIdA01208-
dc.contributor.localIdA02955-
dc.contributor.localIdA03177-
dc.relation.journalcodeJ02100-
dc.identifier.eissn2092-7258-
dc.identifier.pmid22670152-
dc.subject.keywordAngelman syndrome-
dc.subject.keywordAnticonvulsants-
dc.subject.keywordEpilepsy-
dc.contributor.alternativeNameKang, Hoon Chul-
dc.contributor.alternativeNameKim, Heung Dong-
dc.contributor.alternativeNameLee, Young Mock-
dc.contributor.alternativeNameLee, Joon Soo-
dc.contributor.affiliatedAuthorKang, Hoon Chul-
dc.contributor.affiliatedAuthorKim, Heung Dong-
dc.contributor.affiliatedAuthorLee, Young Mock-
dc.contributor.affiliatedAuthorLee, Joon Soo-
dc.citation.volume55-
dc.citation.number5-
dc.citation.startPage171-
dc.citation.endPage176-
dc.identifier.bibliographicCitationKorean Journal of Pediatrics, Vol.55(5) : 171-176, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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