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Effect of Adiponectin and Resistin on Coronary Plaque Composition and Coronary Artery Remodeling of Target Lesion in Patients with Stable Angina

Other Titles
 혈중 Adiponectin과 Resistin의 농도가 안정형 협심증 환자의 표적 병변에서 관상동맥 죽상판의 조성과 관상동맥 재형성에 미치는 영향 
 Jong-Youn Kim  ;  Pil-Ki Min  ;  Young-Won Yoon  ;  Byoung Kwon Lee  ;  Bum-Kee Hong  ;  Hyuck Moon Kwon 
 Journal of Lipid and Atherosclerosis, Vol.1(2) : 69-78, 2012 
Journal Title
 Journal of Lipid and Atherosclerosis 
Issue Date
Adiponectin ; Resistin ; Atherosclerotic plaque ; Intravascular ultrasound ; Arterial remodeling
Objective : The purpose of this study was to investigate the effect of adiponectin and resistin on coronary plaque composition determined by virtual histology (VH) intravascular ultrasound (IVUS) and coronary artery remodeling of target lesion in patients with stable angina. Methods : We prospectively enrolled 48 patients who underwent coronary angiography and VH IVUS for stable angina (27 men, 61±9 years of age). Preintervention grayscale and VH IVUS analysis was done across the target lesion. Planar VH IVUS analysis at the minimum luminal site and volumetric analysis over a 10-mm-long segment centered at the minimum luminal site were performed. The subjects were divided into 2 groups based on remodeling index (RI): positive remodeling (PR) defined as RI>1.0 and non-PR as RI≤1.0. Blood samples for analysis of adiponectin and resistin were obtained from the femoral artery before coronary angioplasty. Results : Of the 48 patients enrolled, 23 (48%) had PR in their target lesion and 25 (52%) were non-PR group. Clinical and angiographic characteristics, VH IVUS parameters were not different between the PR and the non-PR groups. Adiponectin and resistin levels showed no significant correlations with coronary plaque composition evaluated with VH IVUS. Adiponectin showed no significant difference between the two groups. However, resistin showed trend toward higher level in non-PR group (4.17±2.18 ng/mL vs. 6.11±4.26 ng/mL, P=0.056) and a significant negative correlation with RI (r=-0.303, P=0.036). Conclusion : We found a negative correlation between the resistin level and RI of a de-novo target lesion in patients with stable angina.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
권혁문(Kwon, Hyuck Moon) ORCID logo https://orcid.org/0000-0001-9901-5015
김종윤(Kim, Jong Youn) ORCID logo https://orcid.org/0000-0001-7040-8771
민필기(Min, Pil Ki) ORCID logo https://orcid.org/0000-0001-7033-7651
윤영원(Yoon, Young Won) ORCID logo https://orcid.org/0000-0002-0907-0350
이병권(Lee, Byoung Kwon) ORCID logo https://orcid.org/0000-0001-9259-2776
홍범기(Hong, Bum Kee) ORCID logo https://orcid.org/0000-0002-6456-0184
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