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Subclinical hypothyroidism during valproic acid therapy in children and adolescents with epilepsy

Authors
 Se Hee Kim  ;  Hye Rim Chung  ;  Seung Hyo Kim  ;  Hunmin Kim  ;  Byung Chan Lim  ;  Jong Hee Chae  ;  Ki Joong Kim  ;  Yong Seung Hwang  ;  Hee Hwang 
Citation
 NEUROPEDIATRICS, Vol.43(3) : 135-139, 2012 
Journal Title
 NEUROPEDIATRICS 
ISSN
 0174-304X 
Issue Date
2012
MeSH
Adolescent ; Anticonvulsants/adverse effects* ; Anticonvulsants/therapeutic use ; Child ; Child, Preschool ; Epilepsy/blood ; Epilepsy/drug therapy* ; Humans ; Hypothyroidism/blood ; Hypothyroidism/chemically induced* ; Severity of Illness Index ; Thyroid Function Tests ; Thyroid Gland/drug effects ; Thyrotropin/blood ; Thyroxine/blood ; Triiodothyronine/blood ; Valproic Acid/adverse effects* ; Valproic Acid/therapeutic use
Abstract
The aim of this study was to evaluate the incidence of thyroid dysfunction during valproic acid (VPA) therapy in children and adolescents with epilepsy. The serum levels of thyroid-stimulating hormone (TSH), free thyroxine, and triiodothyronine were evaluated in 61 children with epilepsy who received VPA monotherapy for more than 6 months and in 144 controls. We analyzed the effect of age, seizure type, duration of VPA treatment, dose of VPA, and serum level of VPA on thyroid function. The incidence of subclinical hypothyroidism was significantly higher in patients with VPA therapy than in controls (52.4 vs. 16.7%; p < 0.001). In addition, of the 61 patients, 5 (8.1%) exhibited TSH levels that were >10 μIU/mL. However, none of the patients and controls showed overt hypothyroidism. Serum VPA level and daily dose of VPA were correlated with TSH level. Subclinical hypothyroidism developed frequently in children and adolescents during VPA therapy.
Full Text
https://www.thieme-connect.com/DOI/DOI?10.1055/s-0032-1313913
DOI
10.1055/s-0032-1313913
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hee(김세희) ORCID logo https://orcid.org/0000-0001-7773-1942
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158329
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