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Improvement of osteogenic potential of biphasic calcium phosphate bone substitute coated with synthetic cell binding peptide sequences

Authors
 Hyunmin Choi  ;  Nho-Jae Park  ;  Otgonbold Jamiyandorj  ;  Min-Ho Hong  ;  Seunghan Oh  ;  Young-Bum Park  ;  Sungtae Kim 
Citation
 Journal of Periodontal & Implant Science, Vol.42(5) : 166-172, 2012 
Journal Title
 Journal of Periodontal & Implant Science 
ISSN
 2093-2278 
Issue Date
2012
Keywords
Bone regeneration ; Bone substitutes ; Maxillary sinus ; Oligopeptides ; Rabbits
Abstract
Purpose : The aim of this study was to evaluate the improvement of osteogenic potential of biphasic calcium phosphate (BCP) bone substitute coated with synthetic cell-binding peptide sequences in a standardized rabbit sinus model. Methods : Standardized 6-mm diameter defects were created bilaterally on the maxillary sinus of ten male New Zealand white rabbits, receiving BCP bone substitute coated with synthetic cell binding peptide sequences on one side (experimental group) and BCP bone substitute without coating (control group) on the other side. Histologic and histomorphometric analysis of bone formation was carried out after a healing period of 4 or 8 weeks. Results : Histological analysis revealed signs of new bone formation in both experimental groups (4- and 8-week healing groups) with a statistically significant increase in bone formation in the 4-week healing group compared to the control group. However, no statistically significant difference in bone formation was found between the 8-week healing group and the control group. Conclusions : This study found that BCP bone substitute coated with synthetic cell-binding peptide sequences enhanced osteoinductive potential in a standardized rabbit sinus model and its effectiveness was greater in the 4-week healing group than in the 8-week healing group.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158311
DOI
10.5051/jpis.2012.42.5.166
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Science Research Center (구강과학연구소)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실)
Yonsei Authors
박영범(Park, Young Bum) ; 최현민(Choi, Hyun Min) ; 홍민호(Hong, Min Ho)
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