Cited 9 times in
Comparison of the clinical efficacy of medical treatment of symptomatic benign prostatic hyperplasia between normal and obese patients
DC Field | Value | Language |
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dc.contributor.author | 이승환 | - |
dc.contributor.author | 정병하 | - |
dc.date.accessioned | 2018-05-10T06:34:28Z | - |
dc.date.available | 2018-05-10T06:34:28Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1008-682X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/158229 | - |
dc.description.abstract | We aimed to investigate the difference in efficacy of medical treatment of symptomatic benign prostatic hyperplasia (BPH) between normal and obese patients with BPH; obesity was determined by either body mass index (BMI) or waist circumference (WC). In this 12-week prospective observational study, a total of 175 patients aged ≥40 years with International Prostate Symptom Scores (IPSS) ≥12 points and prostate volume ≥20 ml were prospectively enrolled. The patients were divided into two groups according to BMI or WC. Patients received the doxazosin gastrointestinal therapeutic system (GITS) at a dose of 4 mg once per day for 12 weeks. The changes from baseline in the IPSS, maximal urinary flow rate (Q(max)), post-void residual volume, quality of life (QoL) scores and adverse events (AEs) were analysed. Of the 175 enrolled patients, 132 completed the study. Sixty-seven patients had BMI >23 kg m⁻², and 43 had WC >90 cm. Obese patients represented by WC >90 cm or BMI ≥23 kg m⁻² had a significantly greater prostate volume compared with non-obese patients at baseline. Total IPSS was significantly higher in the WC >90 cm group compared to the WC ≤90 cm group. Total IPSS was positively correlated with prostate volume (P=0.031) and WC (P=0.045). All groups showed significant improvements in total IPSS and QoL at 12 weeks. However, the improvement of total IPSS was greater in the high-BMI and high-WC groups. The most frequent AE was dizziness (n=13), and it was significantly lower in the obese BPH patients. Obesity was associated with increased prostate volume and lower urinary tract symptoms. Alpha-blockers appear to be efficacious for controlling symptoms, especially in obese men. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Shanghai Materia Medica | - |
dc.relation.isPartOf | ASIAN JOURNAL OF ANDROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adrenergic alpha-1 Receptor Antagonists/administration & dosage | - |
dc.subject.MESH | Adrenergic alpha-1 Receptor Antagonists/therapeutic use | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Doxazosin/administration & dosage | - |
dc.subject.MESH | Doxazosin/therapeutic use | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Obesity/physiopathology* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Prostatic Hyperplasia/drug therapy* | - |
dc.subject.MESH | Prostatic Hyperplasia/physiopathology | - |
dc.title | Comparison of the clinical efficacy of medical treatment of symptomatic benign prostatic hyperplasia between normal and obese patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Urology | - |
dc.contributor.googleauthor | Seung Hwan Lee | - |
dc.contributor.googleauthor | Cheol Young Oh | - |
dc.contributor.googleauthor | Kyung Kgi Park | - |
dc.contributor.googleauthor | Mun Su Chung | - |
dc.contributor.googleauthor | Se Jeong Yoo | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.identifier.doi | 10.1038/aja.2011.5 | - |
dc.contributor.localId | A02938 | - |
dc.contributor.localId | A03607 | - |
dc.relation.journalcode | J00250 | - |
dc.identifier.eissn | 1745-7262 | - |
dc.identifier.pmid | 21499281 | - |
dc.contributor.alternativeName | Lee, Seung Hwan | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | Lee, Seung Hwan | - |
dc.contributor.affiliatedAuthor | Chung, Byung Ha | - |
dc.citation.volume | 13 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 728 | - |
dc.citation.endPage | 731 | - |
dc.identifier.bibliographicCitation | ASIAN JOURNAL OF ANDROLOGY, Vol.13(5) : 728-731, 2011 | - |
dc.identifier.rimsid | 40626 | - |
dc.type.rims | ART | - |
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