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Role of bone marrow-derived lymphatic endothelial progenitor cells for lymphatic neovascularization

Authors
 Changwon Park  ;  Ji Yoon Lee  ;  Young-sup Yoon 
Citation
 TRENDS IN CARDIOVASCULAR MEDICINE, Vol.21(5) : 135-140, 2011 
Journal Title
 TRENDS IN CARDIOVASCULAR MEDICINE 
ISSN
 1050-1738 
Issue Date
2011
MeSH
Bone Marrow Cells/cytology* ; Endothelial Cells/physiology* ; Humans ; Lymphatic Vessels/physiology ; Membrane Glycoproteins/metabolism ; Neovascularization, Pathologic/physiopathology* ; Stem Cells/physiology*
Abstract
The lymphatic vasculature plays a pivotal role in maintaining tissue fluid homeostasis, immune surveillance, and lipid uptake in the gastrointestinal organs. Therefore, impaired function of the lymphatic vessels caused by genetic defects, infection, trauma, or surgery leads to the abnormal accrual of lymph fluid in the tissue and culminates in the swelling of affected tissues, known as lymphedema. Lymphedema causes impaired wound healing, compromised immune defense, and, in rare case, lymphangiosarcoma. Although millions of people suffer from lymphedema worldwide, no effective therapy is currently available. In addition, recent advances in cancer biology have disclosed an indispensable function of the lymphatic vessel in tumor growth and metastasis. Therefore, understanding the detailed mechanisms governing lymphatic vessel formation and function in pathophysiologic conditions is essential to prevent or treat these diseases. We review the developmental processes of the lymphatic vessels and postnatal lymphatic neovascularization, focusing on the role of recently identified bone marrow-derived podoplanin-expressing (podoplanin(+)) cells as lymphatic endothelial progenitor cells.
Files in This Item:
T201194507.pdf Download
DOI
10.1016/j.tcm.2012.04.002
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Yoon, Young Sup(윤영섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158213
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