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Induced pluripotent stem cells: emerging techniques for nuclear reprogramming

Authors
 Ji Woong Han  ;  Young-sup Yoon 
Citation
 ANTIOXIDANTS & REDOX SIGNALING, Vol.15(7) : 1799-1820, 2011 
Journal Title
 ANTIOXIDANTS & REDOX SIGNALING 
ISSN
 1523-0864 
Issue Date
2011
MeSH
Adenoviridae/genetics ; Animals ; Cell Culture Techniques ; Cell Dedifferentiation/drug effects ; Chromatin ; Enzyme Inhibitors/pharmacology ; Epigenesis, Genetic ; Gene Expression ; Gene Regulatory Networks ; Genetic Engineering ; Genetic Vectors ; Humans ; Induced Pluripotent Stem Cells/cytology* ; Induced Pluripotent Stem Cells/drug effects ; Induced Pluripotent Stem Cells/physiology* ; Induced Pluripotent Stem Cells/transplantation ; Lentivirus/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Regenerative Medicine ; Transcription Factors/genetics ; Transcription Factors/metabolism
Abstract
Introduction of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc, can successfully reprogram somatic cells into embryonic stem (ES)-like cells. These cells, which are referred to as induced pluripotent stem (iPS) cells, closely resemble embryonic stem cells in genomic, cell biologic, and phenotypic characteristics, and the creation of these special cells was a major triumph in cell biology. In contrast to pluripotent stem cells generated by somatic cell nuclear-transfer (SCNT) or ES cells derived from the inner cell mass (ICM) of the blastocyst, direct reprogramming provides a convenient and reliable means of generating pluripotent stem cells. iPS cells have already shown incredible potential for research and for therapeutic applications in regenerative medicine within just a few years of their discovery. In this review, current techniques of generating iPS cells and mechanisms of nuclear reprogramming are reviewed, and the potential for therapeutic applications is discussed.
Files in This Item:
T201194506.pdf Download
DOI
10.1089/ars.2010.3814
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Yoon, Young Sup(윤영섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158212
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