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Induced pluripotent stem cells: emerging techniques for nuclear reprogramming

DC FieldValueLanguage
dc.contributor.author윤영섭-
dc.date.accessioned2018-05-10T06:33:55Z-
dc.date.available2018-05-10T06:33:55Z-
dc.date.issued2011-
dc.identifier.issn1523-0864-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/158212-
dc.description.abstractIntroduction of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc, can successfully reprogram somatic cells into embryonic stem (ES)-like cells. These cells, which are referred to as induced pluripotent stem (iPS) cells, closely resemble embryonic stem cells in genomic, cell biologic, and phenotypic characteristics, and the creation of these special cells was a major triumph in cell biology. In contrast to pluripotent stem cells generated by somatic cell nuclear-transfer (SCNT) or ES cells derived from the inner cell mass (ICM) of the blastocyst, direct reprogramming provides a convenient and reliable means of generating pluripotent stem cells. iPS cells have already shown incredible potential for research and for therapeutic applications in regenerative medicine within just a few years of their discovery. In this review, current techniques of generating iPS cells and mechanisms of nuclear reprogramming are reviewed, and the potential for therapeutic applications is discussed.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMary Ann Liebert, Inc.-
dc.relation.isPartOfANTIOXIDANTS & REDOX SIGNALING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenoviridae/genetics-
dc.subject.MESHAnimals-
dc.subject.MESHCell Culture Techniques-
dc.subject.MESHCell Dedifferentiation/drug effects-
dc.subject.MESHChromatin-
dc.subject.MESHEnzyme Inhibitors/pharmacology-
dc.subject.MESHEpigenesis, Genetic-
dc.subject.MESHGene Expression-
dc.subject.MESHGene Regulatory Networks-
dc.subject.MESHGenetic Engineering-
dc.subject.MESHGenetic Vectors-
dc.subject.MESHHumans-
dc.subject.MESHInduced Pluripotent Stem Cells/cytology*-
dc.subject.MESHInduced Pluripotent Stem Cells/drug effects-
dc.subject.MESHInduced Pluripotent Stem Cells/physiology*-
dc.subject.MESHInduced Pluripotent Stem Cells/transplantation-
dc.subject.MESHLentivirus/genetics-
dc.subject.MESHMicroRNAs/genetics-
dc.subject.MESHMicroRNAs/metabolism-
dc.subject.MESHRecombinant Proteins/genetics-
dc.subject.MESHRecombinant Proteins/metabolism-
dc.subject.MESHRegenerative Medicine-
dc.subject.MESHTranscription Factors/genetics-
dc.subject.MESHTranscription Factors/metabolism-
dc.titleInduced pluripotent stem cells: emerging techniques for nuclear reprogramming-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorJi Woong Han-
dc.contributor.googleauthorYoung-sup Yoon-
dc.identifier.doi10.1089/ars.2010.3814-
dc.contributor.localIdA02579-
dc.relation.journalcodeJ00190-
dc.identifier.eissn1557-7716-
dc.identifier.pmid21194386-
dc.contributor.alternativeNameYoon, Young Sup-
dc.contributor.affiliatedAuthorYoon, Young Sup-
dc.citation.volume15-
dc.citation.number7-
dc.citation.startPage1799-
dc.citation.endPage1820-
dc.identifier.bibliographicCitationANTIOXIDANTS & REDOX SIGNALING, Vol.15(7) : 1799-1820, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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