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Advances in bone marrow-derived cell therapy: CD31-expressing cells as next generation cardiovascular cell therapy

Authors
 Sung-Whan Kim  ;  Hyongbum Kim  ;  Young-sup Yoon 
Citation
 Regenerative Medicine, Vol.6(3) : 335-349, 2011 
Journal Title
 Regenerative Medicine 
ISSN
 1746-0751 
Issue Date
2011
MeSH
Bone Marrow Cells/cytology* ; Bone Marrow Cells/metabolism* ; Bone Marrow Transplantation* ; Cardiovascular Diseases/therapy* ; Cell Differentiation/genetics ; Gene Expression Regulation ; Humans ; Neovascularization, Physiologic/genetics ; Platelet Endothelial Cell Adhesion Molecule-1/chemistry ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism* ; Stem Cells/cytology ; Stem Cells/metabolism
Keywords
angiogenesis ; cardiovascular disease ; CD31 ; ischemia ; progenitors ; stem cells ; vasculogenesis
Abstract
In the past few years, bone marrow (BM)-derived cells have been used to regenerate damaged cardiovascular tissues post-myocardial infarction. Recent clinical trials have shown controversial results in recovering damaged cardiac tissue. New progress has shown that the underlying mechanisms of cell-based therapy relies more heavily on humoral and paracrine effects rather than on new tissue generation. However, studies have also reported the potential of new endothelial cell generation from BM cells. Thus, efforts have been made to identify cells having higher humoral or therapeutic effects as well as their surface markers. Specifically, BM-derived CD31+ cells were isolated by a surface marker and demonstrated high angio-vasculogenic effects. This article will describe recent advances in the therapeutic use of BM-derived cells and the usefulness of CD31+ cells.
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DOI
10.2217/rme.11.24
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Yoon, Young Sup(윤영섭)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158211
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