Drug release from porous hydroxyapatite spheres as a synthetic bone-graft material

Abstract

Hydroxyapatite (HA) is the most commonly used synthetic bone-graft material due to the main component of bones and teeth. However, many research about combining the biological factors and drugs with HA have been performed since a few years ago. We investigated drug(dexamethasone) release behavior after loading to porous spherical HA granules according to the amount of water and sodium chloride as well as the structure of porous HA.