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Potent radiosensitizing agents: 5-methylselenyl- and 5-phenylselenyl-methyl-2'-deoxyuridine

Authors
 Ambadas B. Rode  ;  Byeong Mo Kim  ;  Seon Hwa Park  ;  In Seok Hong  ;  Sung Hee Hong 
Citation
 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol.21(4) : 1151-1154, 2011 
Journal Title
 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 
ISSN
 0960-894X 
Issue Date
2011
MeSH
Cell Line, Tumor ; Deoxyuridine/analogs & derivatives* ; Deoxyuridine/chemical synthesis ; Deoxyuridine/chemistry ; Deoxyuridine/toxicity ; Gamma Rays ; Humans ; Magnetic Resonance Spectroscopy ; Organoselenium Compounds/chemical synthesis ; Organoselenium Compounds/chemistry* ; Organoselenium Compounds/toxicity ; Oxidation-Reduction ; Radiation-Sensitizing Agents/chemical synthesis ; Radiation-Sensitizing Agents/chemistry* ; Radiation-Sensitizing Agents/toxicity
Abstract
This Letter describes the novel radiosensitizing agents based on nucleoside base modification. In addition to the known 5-phenylselenide derivative, 5-methylselenide modified thymidine, which has a van der Waals radius smaller than the phenyl group, was newly synthesized. The similar monomer activity of 5-methylselenide derivative under oxidation condition was confirmed by NMR experiments. The cytotoxicity tests and radiosensitizing experiments of both compounds were carried out using the H460 lung cancer cell line. Both the 5-phenylselenide and the 5-methylselenide derivatives showed a relatively low toxicity to the cells. However, in combination with γ-radiolysis, both exerted good radiosensitizing effects to the lung cancer cell lines in vitro. This result confirms that 5-methylselenide modified thymidine could be a useful candidate as a potential radiosensitizing agent in vivo.
Full Text
https://www.sciencedirect.com/science/article/pii/S0960894X10018664
DOI
10.1016/j.bmcl.2010.12.102
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
Yonsei Authors
Kim, Byeong Mo(김병모) ORCID logo https://orcid.org/0000-0002-0582-3132
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158187
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