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Antitumor activity of methylan polysaccharide derivatives

DC Field Value Language
dc.contributor.author이경미-
dc.date.accessioned2018-05-10T06:31:45Z-
dc.date.available2018-05-10T06:31:45Z-
dc.date.issued2010-
dc.identifier.issn0141-5492-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/158129-
dc.description.abstractMethylan polysaccharide derivatives were prepared by dialkylaminoalkylation and reductive amination followed by quaternization. Their antitumor activity was investigated and a relationship between structure and activity is suggested. For quaternized DEAE-methylan at only 75 mug ml(-1), tumor cell proliferation was suppressed by 58-84% in three cell lines tested in the order Colo < Hela < HepG2.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherKluwer Academic Publishers-
dc.relation.isPartOfBIOTECHNOLOGY LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntineoplastic Agents/chemical synthesis*-
dc.subject.MESHAntineoplastic Agents/pharmacology*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Survival/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHMolecular Structure-
dc.subject.MESHPolysaccharides/chemistry*-
dc.subject.MESHPolysaccharides/pharmacology*-
dc.subject.MESHStructure-Activity Relationship-
dc.titleAntitumor activity of methylan polysaccharide derivatives-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorPriyadharshini Ramachandran-
dc.contributor.googleauthorMarimuthu Jeya-
dc.contributor.googleauthorHee-Jung Moon-
dc.contributor.googleauthorKyoung-Mi Lee-
dc.contributor.googleauthorIn-Won Kim-
dc.contributor.googleauthorJung-Hoe Kim-
dc.contributor.googleauthorJung-Kul Lee-
dc.identifier.doi10.1007/s10529-010-0246-4-
dc.contributor.localIdA04619-
dc.relation.journalcodeJ00336-
dc.identifier.eissn1573-6776-
dc.identifier.pmid20349111-
dc.identifier.urlhttps://link.springer.com/article/10.1007/s10529-010-0246-4-
dc.contributor.alternativeNameLee, Kyoung Mi-
dc.contributor.affiliatedAuthorLee, Kyoung Mi-
dc.citation.volume32-
dc.citation.number7-
dc.citation.startPage891-
dc.citation.endPage895-
dc.identifier.bibliographicCitationBIOTECHNOLOGY LETTERS, Vol.32(7) : 891-895, 2010-
dc.identifier.rimsid48899-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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