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Antitumor activity of methylan polysaccharide derivatives

Authors
 Priyadharshini Ramachandran  ;  Marimuthu Jeya  ;  Hee-Jung Moon  ;  Kyoung-Mi Lee  ;  In-Won Kim  ;  Jung-Hoe Kim  ;  Jung-Kul Lee 
Citation
 BIOTECHNOLOGY LETTERS, Vol.32(7) : 891-895, 2010 
Journal Title
BIOTECHNOLOGY LETTERS
ISSN
 0141-5492 
Issue Date
2010
MeSH
Antineoplastic Agents/chemical synthesis* ; Antineoplastic Agents/pharmacology* ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Molecular Structure ; Polysaccharides/chemistry* ; Polysaccharides/pharmacology* ; Structure-Activity Relationship
Abstract
Methylan polysaccharide derivatives were prepared by dialkylaminoalkylation and reductive amination followed by quaternization. Their antitumor activity was investigated and a relationship between structure and activity is suggested. For quaternized DEAE-methylan at only 75 mug ml(-1), tumor cell proliferation was suppressed by 58-84% in three cell lines tested in the order Colo < Hela < HepG2.
Full Text
https://link.springer.com/article/10.1007/s10529-010-0246-4
DOI
10.1007/s10529-010-0246-4
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Lee, Kyoung Mi(이경미) ORCID logo https://orcid.org/0000-0002-9038-8162
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158129
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