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Ischemic stroke in a 7-month-old infant with antiphospholipid antibody and homozygous C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism

Authors
 Se Hee Kim  ;  Hee Hwang  ;  Jong Hee Chae  ;  Ki Joong Kim  ;  Yong Seung Hwang  ;  Byung Chan Lim 
Citation
 JOURNAL OF CHILD NEUROLOGY, Vol.25(8) : 1047-1050, 2010 
Journal Title
 JOURNAL OF CHILD NEUROLOGY 
ISSN
 0883-0738 
Issue Date
2010
MeSH
Adult ; Antibodies, Antiphospholipid/analysis ; Antibodies, Antiphospholipid/blood* ; Antiphospholipid Syndrome/genetics ; Antiphospholipid Syndrome/physiopathology ; Brain Ischemia/enzymology* ; Brain Ischemia/genetics* ; Brain Ischemia/physiopathology ; DNA Mutational Analysis ; Female ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics* ; Paresis/enzymology ; Paresis/genetics ; Paresis/physiopathology ; Polymorphism, Genetic/genetics* ; Risk Factors ; Stroke/enzymology* ; Stroke/genetics* ; Stroke/physiopathology
Keywords
infant ; stroke ; risk factor ; antiphospholipid antibody ; methylenetetrahydrofolate reductase
Abstract
Prothrombotic risk factors in children with ischemic stroke have been increasingly recognized with recent developments in technology. Extensive evaluation including a detailed family history is required to identify various inherited or acquired prothrombotic conditions. We report a 7-month-old male who presented with right hemiparesis. Acute cerebral infarction in the area supplied by the left lenticulostriate artery was confirmed through magnetic resonance imaging. De novo synthesis of antiphospholipid antibodies and homozygous methylenetetrahydrofolate reductase (MTHFR) polymorphism were identified as presumed prothrombotic risk factors. His twin sister and mother were also positive for antiphospholipid antibodies. Multiple risk factors for ischemic stroke should be considered, particularly in the perinatal and infancy period. This case also underlines the rare familial occurrence of antiphospholipid antibodies and its relationship to ischemic stroke in infancy.
Full Text
http://journals.sagepub.com/doi/abs/10.1177/0883073809356710
DOI
10.1177/0883073809356710
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hee(김세희) ORCID logo https://orcid.org/0000-0001-7773-1942
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158119
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