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계란 알레르기에서 열처리한 계란을 이용한 피부단자시험의 진단적 유용성

Other Titles
 Diagnostic utility of skin prick test to cooked egg in children with egg allergy 
Authors
 전진  ;  이경은  ;  김미나  ;  홍정연  ;  김민정  ;  김윤희  ;  박현빈  ;  한윤기  ;  이희선  ;  김경원  ;  손명현  ;  박중원  ;  김규언 
Citation
 Allergy Asthma & Respiratory Disease, Vol.3(1) : 22-29, 2015 
Journal Title
 Allergy Asthma & Respiratory Disease 
ISSN
 2288-0402 
Issue Date
2015
Keywords
Egg hypersensitivity ; Skin tests ; Egg proteins
Abstract
Purpose : Reliable predictors of tolerance to cooked egg in an egg allergic population are not established. We investigated the usefulness of the skin prick test to cooked egg in children with egg allergy. Methods : We studied 36 children with egg allergy. Skin prick tests (SPTs) for the uncooked or cooked form of egg white and egg yolk, whole egg, ovomucoid (OVM), and ovalbumin (OVA) were performed at diagnosis. The reagents of cooked egg for SPT were prepared by baking for 25 minutes in 200 degree oven. We also examined specific IgE levels to whole egg, egg white, egg yolk, OVM, and OVA. Results : Patients with history of allergic reaction to extensively heated egg showed significantly increased wheal size for cooked egg white (median [interquartile range]), 10.5 [7.0-14.6] vs. 4.2 [0.0-5.6], P<0.001) and OVM (9.6 [7.3-13.8] vs. 5.6 [0.0-7.8], P=0.001) than those without the history. The strongest positive correlation was found between wheal size for cooked egg white and OVM (r=0.788, P<0.001). SPT wheal size for cooked egg white were positively correlated with serum OVM-specific IgE levels (r=0.691, P<0.001). Cutoff value was 7.0 mm in SPT wheal size for cooked egg white, the sensitivity was 73.1% and specificity was 99.0%. SPT for cooked egg white showed significantly higher area under curve than serum egg white specific IgE. Conclusion : Our results suggest that SPT to cooked egg white may be useful predictor of allergic reaction to cooked egg. Further investigations will be needed.
Files in This Item:
T201506355.pdf Download
DOI
10.4168/aard.2015.3.1.22
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
김규언(Kim, Kyu Earn)
김윤희(Kim, Yoon Hee) ORCID logo https://orcid.org/0000-0002-2149-8501
박중원(Park, Jung Won) ORCID logo https://orcid.org/0000-0003-0249-8749
손명현(Sohn, Myung Hyun) ORCID logo https://orcid.org/0000-0002-2478-487X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157330
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