75 80

Cited 133 times in

Neutrophil trails guide influenza-specific CD8(+) T cells in the airways

DC FieldValueLanguage
dc.contributor.author현영민-
dc.date.accessioned2018-03-26T17:11:07Z-
dc.date.available2018-03-26T17:11:07Z-
dc.date.issued2015-
dc.identifier.issn0036-8075-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157303-
dc.description.abstractDuring viral infections, chemokines guide activated effector T cells to infection sites. However, the cells responsible for producing these chemokines and how such chemokines recruit T cells are unknown. Here, we show that the early recruitment of neutrophils into influenza-infected trachea is essential for CD8(+) T cell-mediated immune protection in mice. We observed that migrating neutrophils leave behind long-lasting trails that are enriched in the chemokine CXCL12. Experiments with granulocyte-specific CXCL12 conditionally depleted mice and a CXCR4 antagonist revealed that CXCL12 derived from neutrophil trails is critical for virus-specific CD8(+) T cell recruitment and effector functions. Collectively, these results suggest that neutrophils deposit long-lasting, chemokine-containing trails, which may provide both chemotactic and haptotactic cues for efficient CD8(+) T cell migration and localization in influenza-infected tissues.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Association for the Advancement of Science-
dc.relation.isPartOfSCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCD8-Positive T-Lymphocytes/immunology*-
dc.subject.MESHChemokine CXCL12/immunology*-
dc.subject.MESHChemokine CXCL12/pharmacology-
dc.subject.MESHChemotaxis/immunology*-
dc.subject.MESHHeterocyclic Compounds/pharmacology-
dc.subject.MESHInfluenza A virus/immunology*-
dc.subject.MESHLung/immunology-
dc.subject.MESHLung/virology-
dc.subject.MESHMale-
dc.subject.MESHMatrix Metalloproteinase 2/immunology-
dc.subject.MESHMatrix Metalloproteinase 9/immunology-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHNeutropenia/immunology-
dc.subject.MESHNeutrophils/immunology*-
dc.subject.MESHNeutrophils/virology-
dc.subject.MESHOrthomyxoviridae Infections/immunology*-
dc.subject.MESHTrachea/immunology*-
dc.subject.MESHTrachea/virology-
dc.titleNeutrophil trails guide influenza-specific CD8(+) T cells in the airways-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anatomy-
dc.contributor.googleauthorKihong Lim-
dc.contributor.googleauthorYoung-Min Hyun-
dc.contributor.googleauthorKris Lambert-Emo-
dc.contributor.googleauthorTara Capece-
dc.contributor.googleauthorSeyeon Bae-
dc.contributor.googleauthorRichard Miller-
dc.contributor.googleauthorDavid J. Topham-
dc.contributor.googleauthorMinsoo Kim-
dc.identifier.doi10.1126/science.aaa4352-
dc.contributor.localIdA04814-
dc.relation.journalcodeJ02642-
dc.identifier.eissn1095-9203-
dc.identifier.pmid26339033-
dc.contributor.alternativeNameHyun, Young-Min-
dc.contributor.affiliatedAuthorHyun, Young-Min-
dc.citation.volume349-
dc.citation.number6252-
dc.citation.startPageaaa4352-
dc.identifier.bibliographicCitationSCIENCE, Vol.349(6252) : aaa4352, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.