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Neutrophil trails guide influenza-specific CD8(+) T cells in the airways

Authors
 Kihong Lim  ;  Young-Min Hyun  ;  Kris Lambert-Emo  ;  Tara Capece  ;  Seyeon Bae  ;  Richard Miller  ;  David J. Topham  ;  Minsoo Kim 
Citation
 Science, Vol.349(6252) : aaa4352, 2015 
Journal Title
 Science 
ISSN
 0036-8075 
Issue Date
2015
MeSH
Animals ; CD8-Positive T-Lymphocytes/immunology* ; Chemokine CXCL12/immunology* ; Chemokine CXCL12/pharmacology ; Chemotaxis/immunology* ; Heterocyclic Compounds/pharmacology ; Influenza A virus/immunology* ; Lung/immunology ; Lung/virology ; Male ; Matrix Metalloproteinase 2/immunology ; Matrix Metalloproteinase 9/immunology ; Mice ; Mice, Inbred C57BL ; Neutropenia/immunology ; Neutrophils/immunology* ; Neutrophils/virology ; Orthomyxoviridae Infections/immunology* ; Trachea/immunology* ; Trachea/virology
Abstract
During viral infections, chemokines guide activated effector T cells to infection sites. However, the cells responsible for producing these chemokines and how such chemokines recruit T cells are unknown. Here, we show that the early recruitment of neutrophils into influenza-infected trachea is essential for CD8(+) T cell-mediated immune protection in mice. We observed that migrating neutrophils leave behind long-lasting trails that are enriched in the chemokine CXCL12. Experiments with granulocyte-specific CXCL12 conditionally depleted mice and a CXCR4 antagonist revealed that CXCL12 derived from neutrophil trails is critical for virus-specific CD8(+) T cell recruitment and effector functions. Collectively, these results suggest that neutrophils deposit long-lasting, chemokine-containing trails, which may provide both chemotactic and haptotactic cues for efficient CD8(+) T cell migration and localization in influenza-infected tissues.
Files in This Item:
T201506187.pdf Download
DOI
10.1126/science.aaa4352
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Hyun, Young-Min(현영민) ORCID logo https://orcid.org/0000-0002-0567-2039
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157303
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