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Efficacy and Safety of Sodium Hyaluronate with 1,4-Butanediol Diglycidyl Ether Compared to Sodium Carboxymethylcellulose in Preventing Adhesion Formation after Lumbar Discectomy
DC Field | Value | Language |
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dc.contributor.author | 김긍년 | - |
dc.contributor.author | 신동아 | - |
dc.date.accessioned | 2018-03-26T17:09:43Z | - |
dc.date.available | 2018-03-26T17:09:43Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1738-2262 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157261 | - |
dc.description.abstract | OBJECTIVE: Epidural injection of hyaluronic acid may prevent adhesion formation after spine surgery, but the compounds used to stabilize hyaluronidase could interfere with its anti-adhesion effects. The present study was conducted as a clinical trial to evaluate the efficacy and safety of an experimental medical gel in preventing adhesion formation. METHODS: This study was designed as a multicenter, randomized, double-blind, and comparative controlled clinical trial with an observation period of 6 weeks. Subjects were randomly assigned into two groups: group A with sodium hyaluronate + 1,4-butanediol diglycidyl ether (BDDE) and group B with sodium hyaluronate + sodium carboxymethylcellulose (CMC). Visual analogue scale (VAS) of back and leg pain and the Oswestry disability index (ODI) and scar score ratings were assessed after surgery. RESULTS: Mean scar grade was 2.37±1.13 in group A and 2.75±0.97 in group B, a statistically significant difference (p=0.012). VAS of back and leg pain and ODI scores decreased significantly from baseline to 3 and 6 weeks postoperatively in both groups (p<0.001). However, VAS and ODI scores were not statistically different between groups A and B at baseline or at 3 and 6 weeks after operation (p>0.3). The number of adverse reactions related to the anti-adhesion gels was not statistically different (p=0.569), but subsequent analysis of nervous adverse reactions showed group B was superior with a statistically difference (p=0.027). CONCLUSION: Sodium hyaluronate with BDDE demonstrated similar anti-adhesion properties to sodium hyaluronate with CMC. But, care should be used to nervous adverse reactions by using sodium hyaluronate with BDDE. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | Korean Spinal Neurosurgery Society | - |
dc.relation.isPartOf | Korean Journal of Spine | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Efficacy and Safety of Sodium Hyaluronate with 1,4-Butanediol Diglycidyl Ether Compared to Sodium Carboxymethylcellulose in Preventing Adhesion Formation after Lumbar Discectomy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurosurgery | - |
dc.contributor.googleauthor | Gyu Yeul Ji | - |
dc.contributor.googleauthor | Chang Hyun Oh | - |
dc.contributor.googleauthor | Byung Gwan Moon | - |
dc.contributor.googleauthor | Seong Yi | - |
dc.contributor.googleauthor | In Bo Han | - |
dc.contributor.googleauthor | Dong Hwa Heo | - |
dc.contributor.googleauthor | Ki-Tack Kim | - |
dc.contributor.googleauthor | Dong Ah Shin | - |
dc.contributor.googleauthor | Keung Nyun Kim | - |
dc.identifier.doi | 10.14245/kjs.2015.12.2.41 | - |
dc.contributor.localId | A00331 | - |
dc.contributor.localId | A02092 | - |
dc.relation.journalcode | J02116 | - |
dc.identifier.eissn | 2093-6729 | - |
dc.identifier.pmid | 26217381 | - |
dc.subject.keyword | Anti-adhesion | - |
dc.subject.keyword | Scar formation | - |
dc.subject.keyword | Lumbar discectomy | - |
dc.subject.keyword | Sodium hyaluronate | - |
dc.subject.keyword | 1,4-butanediol diglycidyl ether (BDDE) | - |
dc.subject.keyword | Sodium carboxymethylcellulose (CMC) | - |
dc.contributor.alternativeName | Kim, Keung Nyun | - |
dc.contributor.alternativeName | Shin, Dong A | - |
dc.contributor.affiliatedAuthor | Kim, Keung Nyun | - |
dc.contributor.affiliatedAuthor | Shin, Dong A | - |
dc.citation.volume | 12 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 41 | - |
dc.citation.endPage | 47 | - |
dc.identifier.bibliographicCitation | Korean Journal of Spine, Vol.12(2) : 41-47, 2015 | - |
dc.identifier.rimsid | 41821 | - |
dc.type.rims | ART | - |
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