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A subset of CD45+/CD19 - cells in bone marrow may be associated with clinical outcomes of patients with mantle cell lymphoma
DC Field | Value | Language |
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dc.contributor.author | 이승태 | - |
dc.date.accessioned | 2018-03-26T17:09:41Z | - |
dc.date.available | 2018-03-26T17:09:41Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1042-8194 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157259 | - |
dc.description.abstract | Mantle cell lymphoma has features of both indolent and aggressive non-Hodgkin lymphomas. Repeated relapses leading to treatment failure in patients with mantle cell lymphoma might suggest the presence of cancer stem cells. A small cell population with CD45+/CD19 - was previously reported to represent cancer stem cells. We evaluated the clinical relevance of CD45+/CD19 - cells in bone marrow of patients with mantle cell lymphoma (n = 20). A CD45+/CD19 - cell population was observed in newly diagnosed mantle cell lymphoma, and its percentage correlated with tumor cells in bone marrow (r = 0.832, p = 0.001) and score on the simplified mantle cell lymphoma prognostic index (r = 0.675, p = 0.016). After treatment, CD45+/CD19 - cells decreased (mean: 0.012%), and CD45+/CD19 - cells (0.276%) were higher at relapse or progression than at diagnosis. In conclusion, a CD45+/CD19 - cell population in bone marrow aspirates correlated with the clinical outcome of patients with mantle cell lymphoma. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Informa Healthcare | - |
dc.relation.isPartOf | LEUKEMIA & LYMPHOMA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antigens, CD19/metabolism* | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | Biopsy | - |
dc.subject.MESH | Bone Marrow/pathology | - |
dc.subject.MESH | Bone Marrow Cells/metabolism* | - |
dc.subject.MESH | Bone Marrow Cells/pathology | - |
dc.subject.MESH | Drug Resistance, Neoplasm | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunophenotyping | - |
dc.subject.MESH | Leukocyte Common Antigens/metabolism* | - |
dc.subject.MESH | Lymphoma, Mantle-Cell/drug therapy | - |
dc.subject.MESH | Lymphoma, Mantle-Cell/metabolism* | - |
dc.subject.MESH | Lymphoma, Mantle-Cell/mortality* | - |
dc.subject.MESH | Lymphoma, Mantle-Cell/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Recurrence | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | A subset of CD45+/CD19 - cells in bone marrow may be associated with clinical outcomes of patients with mantle cell lymphoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Laboratory Medicine | - |
dc.contributor.googleauthor | Sung Min Kim | - |
dc.contributor.googleauthor | Seung-Tae Lee | - |
dc.contributor.googleauthor | Kyung Ju Ryu | - |
dc.contributor.googleauthor | Hee-Jin Kim | - |
dc.contributor.googleauthor | Sun-Hee Kim | - |
dc.contributor.googleauthor | Young Hye Ko | - |
dc.contributor.googleauthor | Won Seog Kim | - |
dc.contributor.googleauthor | Seok Jin Kim | - |
dc.identifier.doi | 10.3109/10428194.2015.1025391 | - |
dc.contributor.localId | A04627 | - |
dc.relation.journalcode | J02165 | - |
dc.identifier.eissn | 1029-2403 | - |
dc.identifier.pmid | 25739938 | - |
dc.identifier.url | http://www.tandfonline.com/doi/abs/10.3109/10428194.2015.1025391 | - |
dc.subject.keyword | Cancer stem cell | - |
dc.subject.keyword | bone marrow | - |
dc.subject.keyword | mantle cell lymphoma | - |
dc.contributor.alternativeName | Lee, Seung-Tae | - |
dc.contributor.affiliatedAuthor | Lee, Seung-Tae | - |
dc.citation.volume | 56 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3052 | - |
dc.citation.endPage | 3057 | - |
dc.identifier.bibliographicCitation | LEUKEMIA & LYMPHOMA, Vol.56(11) : 3052-3057, 2015 | - |
dc.identifier.rimsid | 41819 | - |
dc.type.rims | ART | - |
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