Cited 130 times in
The Resting Brain of Alcoholics.
DC Field | Value | Language |
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dc.contributor.author | 정영철 | - |
dc.date.accessioned | 2018-03-26T17:08:51Z | - |
dc.date.available | 2018-03-26T17:08:51Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1047-3211 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157240 | - |
dc.description.abstract | Chronic alcohol consumption affects multiple cognitive processes supported by far-reaching cerebral networks. To identify neurofunctional mechanisms underlying selective deficits, 27 sober alcoholics and 26 age-matched controls underwent resting-state functional magnetic resonance imaging and neuropsychological testing. Functional connectivity analysis assessed the default mode network (DMN); integrative executive control (EC), salience (SA), and attention (AT) networks; primary somatosensory, auditory, and visual (VI) input networks; and subcortical reward (RW) and emotion (EM) networks. The groups showed an extensive overlap of intrinsic connectivity in all brain networks examined, suggesting overall integrity of large-scale functional networks. Despite these similar patterns, connectivity analyses identified network-specific differences of weaker within-network connectivity and expanded connectivity to regions outside the main networks in alcoholics compared with controls. For AT and VI networks, better task performance was related to expanded connectivity in alcoholism, supporting the concept of network expansion as a neural mechanism for functional compensation. For default mode, SA, RW, and EC networks, both weaker within-network and expanded outside-network connectivity correlated with poorer performance and mood. Current smoking contributed to some of these abnormalities in connectivity. The observed pattern of resting-state connectivity might reflect neural vulnerability of intrinsic networking in alcoholics and suggests a mechanism to explain signature impairments in EM, RW evaluation, and EC ability. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | CEREBRAL CORTEX | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alcoholism/pathology* | - |
dc.subject.MESH | Brain/blood supply | - |
dc.subject.MESH | Brain/physiopathology* | - |
dc.subject.MESH | Brain Mapping* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Image Processing, Computer-Assisted | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neural Pathways/blood supply | - |
dc.subject.MESH | Neural Pathways/physiopathology* | - |
dc.subject.MESH | Oxygen/blood | - |
dc.subject.MESH | Rest* | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.title | The Resting Brain of Alcoholics. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Psychiatry | - |
dc.contributor.googleauthor | Eva M. Müller-Oehring | - |
dc.contributor.googleauthor | Young-Chul Jung | - |
dc.contributor.googleauthor | Adolf Pfefferbaum | - |
dc.contributor.googleauthor | Edith V. Sullivan | - |
dc.contributor.googleauthor | Tilman Schulte | - |
dc.identifier.doi | 10.1093/cercor/bhu134 | - |
dc.contributor.localId | A03656 | - |
dc.relation.journalcode | J00505 | - |
dc.identifier.eissn | 1460-2199 | - |
dc.identifier.pmid | 24935777 | - |
dc.subject.keyword | alcoholism | - |
dc.subject.keyword | cerebral networks | - |
dc.subject.keyword | cognition and emotion | - |
dc.subject.keyword | fMRI | - |
dc.subject.keyword | resting-state functional connectivity | - |
dc.contributor.alternativeName | Jung, Young Chul | - |
dc.contributor.affiliatedAuthor | Jung, Young Chul | - |
dc.citation.volume | 25 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 4155 | - |
dc.citation.endPage | 4168 | - |
dc.identifier.bibliographicCitation | CEREBRAL CORTEX, Vol.25(11) : 4155-4168, 2015 | - |
dc.identifier.rimsid | 41800 | - |
dc.type.rims | ART | - |
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