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The Resting Brain of Alcoholics.

DC Field Value Language
dc.contributor.author정영철-
dc.date.accessioned2018-03-26T17:08:51Z-
dc.date.available2018-03-26T17:08:51Z-
dc.date.issued2015-
dc.identifier.issn1047-3211-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157240-
dc.description.abstractChronic alcohol consumption affects multiple cognitive processes supported by far-reaching cerebral networks. To identify neurofunctional mechanisms underlying selective deficits, 27 sober alcoholics and 26 age-matched controls underwent resting-state functional magnetic resonance imaging and neuropsychological testing. Functional connectivity analysis assessed the default mode network (DMN); integrative executive control (EC), salience (SA), and attention (AT) networks; primary somatosensory, auditory, and visual (VI) input networks; and subcortical reward (RW) and emotion (EM) networks. The groups showed an extensive overlap of intrinsic connectivity in all brain networks examined, suggesting overall integrity of large-scale functional networks. Despite these similar patterns, connectivity analyses identified network-specific differences of weaker within-network connectivity and expanded connectivity to regions outside the main networks in alcoholics compared with controls. For AT and VI networks, better task performance was related to expanded connectivity in alcoholism, supporting the concept of network expansion as a neural mechanism for functional compensation. For default mode, SA, RW, and EC networks, both weaker within-network and expanded outside-network connectivity correlated with poorer performance and mood. Current smoking contributed to some of these abnormalities in connectivity. The observed pattern of resting-state connectivity might reflect neural vulnerability of intrinsic networking in alcoholics and suggests a mechanism to explain signature impairments in EM, RW evaluation, and EC ability.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfCEREBRAL CORTEX-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlcoholism/pathology*-
dc.subject.MESHBrain/blood supply-
dc.subject.MESHBrain/physiopathology*-
dc.subject.MESHBrain Mapping*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImage Processing, Computer-Assisted-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHNeural Pathways/blood supply-
dc.subject.MESHNeural Pathways/physiopathology*-
dc.subject.MESHOxygen/blood-
dc.subject.MESHRest*-
dc.subject.MESHStatistics, Nonparametric-
dc.titleThe Resting Brain of Alcoholics.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Psychiatry-
dc.contributor.googleauthorEva M. Müller-Oehring-
dc.contributor.googleauthorYoung-Chul Jung-
dc.contributor.googleauthorAdolf Pfefferbaum-
dc.contributor.googleauthorEdith V. Sullivan-
dc.contributor.googleauthorTilman Schulte-
dc.identifier.doi10.1093/cercor/bhu134-
dc.contributor.localIdA03656-
dc.relation.journalcodeJ00505-
dc.identifier.eissn1460-2199-
dc.identifier.pmid24935777-
dc.subject.keywordalcoholism-
dc.subject.keywordcerebral networks-
dc.subject.keywordcognition and emotion-
dc.subject.keywordfMRI-
dc.subject.keywordresting-state functional connectivity-
dc.contributor.alternativeNameJung, Young Chul-
dc.contributor.affiliatedAuthorJung, Young Chul-
dc.citation.volume25-
dc.citation.number11-
dc.citation.startPage4155-
dc.citation.endPage4168-
dc.identifier.bibliographicCitationCEREBRAL CORTEX, Vol.25(11) : 4155-4168, 2015-
dc.identifier.rimsid41800-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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