Cited 27 times in
Antipsychotic Prescribing Patterns in First-episode Schizophrenia: A Five-year Comparison
DC Field | Value | Language |
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dc.contributor.author | 김찬형 | - |
dc.contributor.author | 장진구 | - |
dc.date.accessioned | 2018-03-26T17:07:24Z | - |
dc.date.available | 2018-03-26T17:07:24Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1738-1088 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157216 | - |
dc.description.abstract | OBJECTIVE: Early treatment choice is critical in first-episode schizophrenia-spectrum disorders. The purpose of this study was to describe prescribing trends of antipsychotics use in patients with first-episode schizophrenia in 2005 and 2010, respectively. METHODS: We reviewed the medical records of newly treated patients with schizophrenia from a university psychiatric hospital in 2005 (n=47) and 2010 (n=52). We defined patients as receiving a high antipsychotic dose if their ratio of prescribed daily dose (PDD) to defined daily dose (DDD) was greater than 1.5. RESULTS: The rates of high-dose antipsychotic prescription were 61.7% and 53.8% in 2005 and 2010, respectively. The rates of antipsychotic polypharmacy were 34.6% in 2005 and 34.0% in 2010. The most common first-prescribed antipsychotics were (in descending order of prescription frequency) olanzapine, risperidone, aripiprazole, and haloperidol in 2005 and risperidone, quetiapine, paliperidone, and olanzapine in 2010. High-dose antipsychotics were significantly associated with antipsychotic polypharmacy (odds ratio=23.97; p<0.01). More individuals were treated with mood stabilizers in 2010 than in 2005 (p=0.003). CONCLUSION: The practice of prescribing high-dose antipsychotics and associated antipsychotic polypharmacy were common even for initial treatment of first-episode schizophrenia in 2005 and 2010. In 2010, the list of the most common first-prescribed antipsychotics changed, and the use of mood stabilizers increased in non-affective schizophrenia. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English, Korean | - |
dc.publisher | Korean College of Neuropsychopharmacology | - |
dc.relation.isPartOf | CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Antipsychotic Prescribing Patterns in First-episode Schizophrenia: A Five-year Comparison | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Psychiatry | - |
dc.contributor.googleauthor | Daeyoung Roh | - |
dc.contributor.googleauthor | Jhin-Goo Chang | - |
dc.contributor.googleauthor | Sol Yoon | - |
dc.contributor.googleauthor | Chan-Hyung Kim | - |
dc.identifier.doi | 10.9758/cpn.2015.13.3.275 | - |
dc.contributor.localId | A01036 | - |
dc.relation.journalcode | J00609 | - |
dc.identifier.eissn | 2093-4327 | - |
dc.identifier.pmid | 26598586 | - |
dc.subject.keyword | Antimanic agents | - |
dc.subject.keyword | Antipsychotic agents | - |
dc.subject.keyword | First-episode | - |
dc.subject.keyword | Polypharmacy | - |
dc.subject.keyword | Schizophrenia | - |
dc.contributor.alternativeName | Kim, Chan Hyung | - |
dc.contributor.affiliatedAuthor | Kim, Chan Hyung | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 275 | - |
dc.citation.endPage | 282 | - |
dc.identifier.bibliographicCitation | CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, Vol.13(3) : 275-282, 2015 | - |
dc.identifier.rimsid | 41776 | - |
dc.type.rims | ART | - |
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