Cited 35 times in
Current but not past smoking increases the risk of cardiac events: insights from coronary computed tomographic angiography
DC Field | Value | Language |
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dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2018-03-26T17:04:00Z | - |
dc.date.available | 2018-03-26T17:04:00Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0195-668X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157134 | - |
dc.description.abstract | AIMS: We evaluated coronary artery disease (CAD) extent, severity, and major adverse cardiac events (MACEs) in never, past, and current smokers undergoing coronary CT angiography (CCTA). METHODS AND RESULTS: We evaluated 9456 patients (57.1 ± 12.3 years, 55.5% male) without known CAD (1588 current smokers; 2183 past smokers who quit ≥3 months before CCTA; and 5685 never smokers). By risk-adjusted Cox proportional-hazards models, we related smoking status to MACE (all-cause death or non-fatal myocardial infarction). We further performed 1:1:1 propensity matching for 1000 in each group evaluate event risk among individuals with similar age, gender, CAD risk factors, and symptom presentation. During a mean follow-up of 2.8 ± 1.9 years, 297 MACE occurred. Compared with never smokers, current and past smokers had greater atherosclerotic burden including extent of plaque defined as segments with any plaque (2.1 ± 2.8 vs. 2.6 ± 3.2 vs. 3.1 ± 3.3, P < 0.0001) and prevalence of obstructive CAD [1-vessel disease (VD): 10.6% vs. 14.9% vs. 15.2%, P < 0.001; 2-VD: 4.4% vs. 6.1% vs. 6.2%, P = 0.001; 3-VD: 3.1% vs. 5.2% vs. 4.3%, P < 0.001]. Compared with never smokers, current smokers experienced higher MACE risk [hazard ratio (HR) 1.9, 95% confidence interval (CI) 1.4-2.6, P < 0.001], while past smokers did not (HR 1.2, 95% CI 0.8-1.6, P = 0.35). Among matched individuals, current smokers had higher MACE risk (HR 2.6, 95% CI 1.6-4.2, P < 0.001), while past smokers did not (HR 1.3, 95% CI 0.7-2.4, P = 0.39). Similar findings were observed for risk of all-cause death. CONCLUSION: Among patients without known CAD undergoing CCTA, current and past smokers had increased burden of atherosclerosis compared with never smokers; however, risk of MACE was heightened only in current smokers. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | EUROPEAN HEART JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Coronary Angiography/methods | - |
dc.subject.MESH | Coronary Artery Disease/diagnostic imaging | - |
dc.subject.MESH | Coronary Artery Disease/etiology* | - |
dc.subject.MESH | Coronary Artery Disease/mortality | - |
dc.subject.MESH | Epidemiologic Methods | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Infarction/diagnostic imaging | - |
dc.subject.MESH | Myocardial Infarction/etiology | - |
dc.subject.MESH | Myocardial Infarction/mortality | - |
dc.subject.MESH | Plaque, Atherosclerotic/diagnostic imaging | - |
dc.subject.MESH | Plaque, Atherosclerotic/etiology | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Smoking/adverse effects* | - |
dc.subject.MESH | Tomography, X-Ray Computed/methods | - |
dc.title | Current but not past smoking increases the risk of cardiac events: insights from coronary computed tomographic angiography | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Rine Nakanishi | - |
dc.contributor.googleauthor | Daniel S. Berman | - |
dc.contributor.googleauthor | Matthew J. Budoff | - |
dc.contributor.googleauthor | Heidi Gransar | - |
dc.contributor.googleauthor | Stephan Achenbach | - |
dc.contributor.googleauthor | Mouaz Al-Mallah | - |
dc.contributor.googleauthor | Daniele Andreini | - |
dc.contributor.googleauthor | Filippo Cademartiri | - |
dc.contributor.googleauthor | Tracy Q. Callister | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Victor Y. Cheng | - |
dc.contributor.googleauthor | Kavitha Chinnaiyan | - |
dc.contributor.googleauthor | Benjamin J.W. Chow | - |
dc.contributor.googleauthor | Ricardo Cury | - |
dc.contributor.googleauthor | Augustin Delago | - |
dc.contributor.googleauthor | Martin Hadamitzky | - |
dc.contributor.googleauthor | Jo¨ rg Hausleiter | - |
dc.contributor.googleauthor | Gudrun Feuchtner | - |
dc.contributor.googleauthor | Yong-Jin Kim | - |
dc.contributor.googleauthor | Philipp A. Kaufmann | - |
dc.contributor.googleauthor | Jonathon Leipsic | - |
dc.contributor.googleauthor | Fay Y. Lin | - |
dc.contributor.googleauthor | Erica Maffei | - |
dc.contributor.googleauthor | Gianluca Pontone | - |
dc.contributor.googleauthor | Gilbert Raff | - |
dc.contributor.googleauthor | Leslee J. Shaw | - |
dc.contributor.googleauthor | Todd C. Villines | - |
dc.contributor.googleauthor | Allison Dunning | - |
dc.contributor.googleauthor | James K. Min | - |
dc.identifier.doi | 10.1093/eurheartj/ehv013 | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J00805 | - |
dc.identifier.eissn | 1522-9645 | - |
dc.identifier.pmid | 25666322 | - |
dc.subject.keyword | Coronary atherosclerosis | - |
dc.subject.keyword | Coronary computed tomographic angiography | - |
dc.subject.keyword | Major adverse cardiovascular risk | - |
dc.subject.keyword | Smoking risk | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | Chang, Hyuck Jae | - |
dc.citation.volume | 36 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 1031 | - |
dc.citation.endPage | 1040 | - |
dc.identifier.bibliographicCitation | EUROPEAN HEART JOURNAL, Vol.36(17) : 1031-1040, 2015 | - |
dc.identifier.rimsid | 41697 | - |
dc.type.rims | ART | - |
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