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Cutaneous Serratia marcescens infections in Korea: A retrospective analysis of 13 patients

DC FieldValueLanguage
dc.contributor.author김대석-
dc.contributor.author서지명-
dc.contributor.author신동윤-
dc.contributor.author오상호-
dc.contributor.author이민걸-
dc.contributor.author이주희-
dc.contributor.author정기양-
dc.date.accessioned2018-03-26T17:03:54Z-
dc.date.available2018-03-26T17:03:54Z-
dc.date.issued2015-
dc.identifier.issn0385-2407-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157133-
dc.description.abstractSerratia marcescens is a Gram-negative bacillus belonging to the Enterobacteriaceae family. Because of increasing reports of antimicrobial resistance, this bacterium has received considerable attention and has emerged as an important pathogen. In order to reveal clinical and microbiological characteristics of S. marcescens cutaneous infection and to suggest appropriate antibiotic treatment, we retrospectively analyzed 17 strains isolated from wound swabs of Korean patients between November 2005 and March 2014. A total of 13 patients (five men and eight women) were included in our study, with a mean age of 46.3 years (range, 21-82). Based on medical history, seven patients were classified as immunocompromised. Prior predisposing factors for infections were noted in 12 patients, including pre-existing leg ulcers or dermatitis (5/13), preceding cancer surgeries (2/13), plastic surgeries and filler injection (2/13), traumas (2/13) and medical procedures following cutaneous abscess (1/13). Cutaneous infections showed various clinical presentations, including spontaneous dermal abscess, fingernail change, painful nodules and papular erosions. We found that third- and fourth-generation cephalosporins, gentamicin, levofloxacin and meropenem appeared active against all 17 strains in vitro. Clinically, all patients treated with empirical first-generation cephalosporin showed treatment resistance, and oral quinolone monotherapy was the most preferred antibiotic regimen without treatment failure, with an average treatment duration of 25 days (range, 14-42). This study demonstrates the various clinical presentations and treatment responses for cutaneous S. marcescens infection. Moreover, we suggest that initial antibiotic coverage should be broad enough to account for multidrug resistance in this rare pathogen.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfJOURNAL OF DERMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHDrug Resistance, Multiple, Bacterial-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSerratia Infections/diagnosis-
dc.subject.MESHSerratia Infections/drug therapy-
dc.subject.MESHSerratia Infections/microbiology*-
dc.subject.MESHSerratia marcescens*/drug effects-
dc.subject.MESHSerratia marcescens*/isolation & purification-
dc.subject.MESHSkin Diseases, Bacterial/diagnosis-
dc.subject.MESHSkin Diseases, Bacterial/drug therapy-
dc.subject.MESHSkin Diseases, Bacterial/microbiology*-
dc.subject.MESHYoung Adult-
dc.titleCutaneous Serratia marcescens infections in Korea: A retrospective analysis of 13 patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Dermatology-
dc.contributor.googleauthorJimyung SEO-
dc.contributor.googleauthorDongyun SHIN-
dc.contributor.googleauthorSang Ho OH-
dc.contributor.googleauthorJu Hee LEE-
dc.contributor.googleauthorKee Yang CHUNG-
dc.contributor.googleauthorMin-Geol LEE-
dc.contributor.googleauthorDae Suk KIM-
dc.identifier.doi10.1111/1346-8138.13059-
dc.contributor.localIdA00366-
dc.contributor.localIdA04583-
dc.contributor.localIdA05246-
dc.contributor.localIdA02370-
dc.contributor.localIdA02779-
dc.contributor.localIdA03171-
dc.contributor.localIdA03582-
dc.relation.journalcodeJ01372-
dc.identifier.eissn1346-8138-
dc.identifier.pmid26241516-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/1346-8138.13059/abstract-
dc.subject.keywordSerratia marcescens-
dc.subject.keywordantimicrobial resistance-
dc.subject.keywordcutaneous infection-
dc.subject.keywordhost immune status-
dc.subject.keywordrisk factors-
dc.contributor.alternativeNameKim, Dae Suk-
dc.contributor.alternativeNameSeo, Jimyung-
dc.contributor.alternativeNameShin, Dong Yun-
dc.contributor.alternativeNameOh, Sang Ho-
dc.contributor.alternativeNameLee, Min Geol-
dc.contributor.alternativeNameLee, Ju Hee-
dc.contributor.alternativeNameChung, Kee Yang-
dc.contributor.affiliatedAuthorKim, Dae Suk-
dc.contributor.affiliatedAuthorSeo, Jimyung-
dc.contributor.affiliatedAuthorShin, Dong Yun-
dc.contributor.affiliatedAuthorOh, Sang Ho-
dc.contributor.affiliatedAuthorLee, Min Geol-
dc.contributor.affiliatedAuthorLee, Ju Hee-
dc.contributor.affiliatedAuthorChung, Kee Yang-
dc.citation.volume43-
dc.citation.number2-
dc.citation.startPage149-
dc.citation.endPage155-
dc.identifier.bibliographicCitationJOURNAL OF DERMATOLOGY, Vol.43(2) : 149-155, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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