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Association between Chemotherapy-Response Assays and Subsets of Tumor-Infiltrating Lymphocytes in Gastric Cancer: A Pilot Study

DC FieldValueLanguage
dc.contributor.author김충배-
dc.contributor.author김형일-
dc.contributor.author노성훈-
dc.contributor.author손태일-
dc.contributor.author이지연-
dc.contributor.author정재호-
dc.contributor.author형우진-
dc.date.accessioned2018-03-26T17:03:41Z-
dc.date.available2018-03-26T17:03:41Z-
dc.date.issued2015-
dc.identifier.issn2093-582X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157129-
dc.description.abstractPURPOSE: The purpose of this pilot study was to evaluate the association between adenosine triphosphate-based chemotherapy response assays (ATP-CRAs) and subsets of tumor infiltrating lymphocytes (TILs) in gastric cancer. MATERIALS AND METHODS: In total, 15 gastric cancer tissue samples were obtained from gastrectomies performed between February 2007 and January 2011. Chemotherapy response assays were performed on tumor cells from these samples using 11 chemotherapeutic agents, including etoposide, doxorubicin, epirubicin, mitomycin, 5-fluorouracil (5-FU), oxaliplatin, irinotecan, docetaxel, paclitaxel, methotrexate, and cisplatin. TILs in the tissue samples were evaluated using antibodies specific for CD3, CD4, CD8, Foxp3, and Granzyme B. RESULTS: The highest cancer cell death rates were induced by etoposide (44.8%), 5-FU (43.1%), and mitomycin (39.9%). Samples from 10 patients who were treated with 5-FU were divided into 5-FU-sensitive and -insensitive groups according to median cell death rate. No difference was observed in survival between the two groups (P=0.216). Only two patients were treated with a chemotherapeutic agent determined by an ATP-CRA and there was no significant difference in overall survival compared with that of patients treated with their physician's choice of chemotherapeutic agent (P=0.105). However, a high number of CD3 TILs was a favorable prognostic factor (P=0.008). Pearson's correlation analyses showed no association between cancer cell death rates in response to chemotherapeutic agents and subsets of TILs. CONCLUSIONS: Cancer cell death rates in response to specific chemotherapeutic agents were not significantly associated with the distribution of TIL subsets.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Gastric Cancer Association-
dc.relation.isPartOfJOURNAL OF GASTRIC CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAssociation between Chemotherapy-Response Assays and Subsets of Tumor-Infiltrating Lymphocytes in Gastric Cancer: A Pilot Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorJee Youn Lee-
dc.contributor.googleauthorTaeil Son-
dc.contributor.googleauthorJae-Ho Cheong-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorChoong-Bai Kim-
dc.contributor.googleauthorChung-Gyu Park-
dc.contributor.googleauthorHyoung-Il Kim-
dc.identifier.doi10.5230/jgc.2015.15.4.223-
dc.contributor.localIdA01063-
dc.contributor.localIdA01154-
dc.contributor.localIdA01281-
dc.contributor.localIdA01998-
dc.contributor.localIdA04787-
dc.contributor.localIdA03717-
dc.contributor.localIdA04382-
dc.relation.journalcodeJ01415-
dc.identifier.eissn2093-5641-
dc.identifier.pmid26819801-
dc.subject.keywordAdenosine triphosphate-
dc.subject.keywordChemotherapy response assay-
dc.subject.keywordDrug screening assays, antitumor-
dc.subject.keywordLymphocytes, tumor-infiltrating-
dc.subject.keywordStomach neoplasms-
dc.contributor.alternativeNameKim, Choong Bai-
dc.contributor.alternativeNameKim, Hyoung Il-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameSon, Tae Il-
dc.contributor.alternativeNameLee, Jee Youn-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.alternativeNameHyung, Woo Jin-
dc.contributor.affiliatedAuthorKim, Choong Bai-
dc.contributor.affiliatedAuthorKim, Hyoung Il-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorSon, Tae Il-
dc.contributor.affiliatedAuthorLee, Jee Youn-
dc.contributor.affiliatedAuthorCheong, Jae Ho-
dc.contributor.affiliatedAuthorHyung, Woo Jin-
dc.citation.volume15-
dc.citation.number4-
dc.citation.startPage223-
dc.citation.endPage230-
dc.identifier.bibliographicCitationJOURNAL OF GASTRIC CANCER, Vol.15(4) : 223-230, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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