Cited 20 times in
Oxidative damage markers are significantly associated with the carotid artery intima-media thickness after controlling for conventional risk factors of atherosclerosis in men
DC Field | Value | Language |
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dc.contributor.author | 윤진하 | - |
dc.date.accessioned | 2018-03-26T16:58:40Z | - |
dc.date.available | 2018-03-26T16:58:40Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157033 | - |
dc.description.abstract | BACKGROUND: This study aimed to assess the association between oxidative damage markers and carotid artery intima-media thickness (CIMT) after controlling for conventional risk factors of atherosclerosis in multiple logistic regression models. METHODS AND FINDINGS: Fifty-one case male participants (CIMT ≥ 0.9 mm) were enrolled during their visits to Korean Genomic Rural Cohort Study of Wonju centers between May 1 and August 31, 2011, along with 51 control participants (CIMT < 0.9 mm) selected using frequency matching by age group. The levels of oxidative damage markers, 8-hydroxy-2'-deoxyquuanosine (8-OHdG), malondialdehyde (MDA), and 8-iso-prostaglandin F2α (Isoprostane), were measured. Conditional logistic regression models were used to evaluate relative relationships between the oxidative damage markers and the risk of high CIMT. RESULTS: The markers of oxidative lipid (Isoprostane and MDA) and DNA (8-OHdG) damage were associated with CIMT after controlling for the conventional risk factors, including age, low density lipoprotein, body mass index, smoking history, alcohol consumption, and metabolic syndrome (ORs [95% CI] for Isoprostane: 3rd tertile, 8.47 [2.59-27.67]; for MDA: 3rd tertile, 8.47 [2.59-27.67]; for 8-OHdG: 3rd tertile, 5.58 [1.79-17.33]). When all the oxidative damage markers were incorporated in the same logistic regression model, only Isoprostane was significantly related to CIMT (OR [95% CI]: 4.22 [1.31-13.53] in 2nd tertile and 14.21 [3.34-60.56] in 3rd tertile). CONCLUSIONS: In this nested case-control study, the oxidative damage markers of lipid and DNA were associated with CIMT even after controlling for the conventional risk factors of cardiovascular diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Atherosclerosis/diagnostic imaging | - |
dc.subject.MESH | Atherosclerosis/etiology* | - |
dc.subject.MESH | Atherosclerosis/metabolism | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Carotid Arteries/diagnostic imaging | - |
dc.subject.MESH | Carotid Arteries/metabolism* | - |
dc.subject.MESH | Carotid Artery Diseases/diagnostic imaging | - |
dc.subject.MESH | Carotid Artery Diseases/etiology* | - |
dc.subject.MESH | Carotid Artery Diseases/metabolism | - |
dc.subject.MESH | Carotid Intima-Media Thickness | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Deoxyguanosine/analogs & derivatives | - |
dc.subject.MESH | Deoxyguanosine/blood | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Isoprostanes/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Malondialdehyde/blood | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Oxidative Stress/physiology* | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Oxidative damage markers are significantly associated with the carotid artery intima-media thickness after controlling for conventional risk factors of atherosclerosis in men | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Preventive Medicine | - |
dc.contributor.googleauthor | Jin-Ha Yoon | - |
dc.contributor.googleauthor | Jang-Young Kim | - |
dc.contributor.googleauthor | Jong-Ku Park | - |
dc.contributor.googleauthor | Sang-Baek Ko | - |
dc.identifier.doi | 10.1371/journal.pone.0119731 | - |
dc.contributor.localId | A04616 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 25806957 | - |
dc.contributor.alternativeName | Yoon, Jin Ha | - |
dc.contributor.affiliatedAuthor | Yoon, Jin Ha | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | e0119731 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.10(3) : e0119731, 2015 | - |
dc.identifier.rimsid | 41342 | - |
dc.type.rims | ART | - |
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