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Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: A prospective multicentre study (WISS Study)

Authors
 Massimo Sartelli  ;  Fikri M. Abu-Zidan  ;  Fausto Catena  ;  Ewen A. Griffiths  ;  Salomone Di Saverio  ;  Raul Coimbra  ;  Carlos A. Ordoñez  ;  Ari Leppaniemi  ;  Gustavo P. Fraga  ;  Federico Coccolini  ;  Ferdinando Agresta  ;  Asrhaf Abbas  ;  Saleh Abdel Kader  ;  John Agboola  ;  Adamu Amhed  ;  Adesina Ajibade  ;  Seckin Akkucuk  ;  Bandar Alharthi  ;  Dimitrios Anyfantakis  ;  Goran Augustin  ;  Gianluca Baiocchi  ;  Miklosh Bala  ;  Oussama Baraket  ;  Savas Bayrak  ;  Giovanni Bellanova  ;  Marcelo A. Beltràn  ;  Roberto Bini  ;  Matthew Boal  ;  Andrey V. Borodach  ;  Konstantinos Bouliaris  ;  Frederic Branger  ;  Daniele Brunelli  ;  Marco Catani  ;  Asri Che Jusoh  ;  Alain Chichom-Mefire  ;  Gianfranco Cocorullo  ;  Elif Colak  ;  David Costa  ;  Silvia Costa  ;  Yunfeng Cui  ;  Geanina Loredana Curca  ;  Terry Curry  ;  Koray Das  ;  Samir Delibegovic  ;  Zaza Demetrashvili  ;  Isidoro Di Carlo  ;  Nadezda Drozdova  ;  Tamer El Zalabany  ;  Mushira Abdulaziz Enani  ;  Mario Faro  ;  Mahir Gachabayov  ;  Teresa Giménez Maurel  ;  Georgios Gkiokas  ;  Carlos Augusto Gomes  ;  Ricardo Alessandro Teixeira Gonsaga  ;  Gianluca Guercioni  ;  Ali Guner  ;  Sanjay Gupta  ;  Sandra Gutierrez  ;  Martin Hutan  ;  Orestis Ioannidis  ;  Arda Isik  ;  Yoshimitsu Izawa  ;  Sumita A. Jain  ;  Mantas Jokubauskas  ;  Aleksandar Karamarkovic  ;  Saila Kauhanen  ;  Robin Kaushik  ;  Jakub Kenig  ;  Vladimir Khokha  ;  Jae Il Kim  ;  Victor Kong  ;  Renol Koshy  ;  Avidyl Krasniqi  ;  Ashok Kshirsagar  ;  Zygimantas Kuliesius  ;  Konstantinos Lasithiotakis  ;  Pedro Leão  ;  Jae Gil Lee  ;  Miguel Leon  ;  Aintzane Lizarazu Pérez  ;  Varut Lohsiriwat  ;  Eudaldo López-Tomassetti Fernandez  ;  Eftychios Lostoridis  ;  Raghuveer Mn  ;  Piotr Major  ;  Athanasios Marinis  ;  Daniele Marrelli  ;  Aleix Martinez-Perez  ;  Sanjay Marwah  ;  Michael McFarlane  ;  Renato Bessa Melo  ;  Cristian Mesina  ;  Nick Michalopoulos  ;  Radu Moldovanu  ;  Ouadii Mouaqit  ;  Akutu Munyika  ;  Ionut Negoi  ;  Ioannis Nikolopoulos  ;  Gabriela Elisa Nita  ;  Iyiade Olaoye  ;  Abdelkarim Omari  ;  Paola Rodríguez Ossa  ;  Zeynep Ozkan  ;  Ramakrishnapillai Padmakumar  ;  Francesco Pata  ;  Gerson Alves Pereira Junior  ;  Jorge Pereira  ;  Tadeja Pintar  ;  Konstantinos Pouggouras  ;  Vinod Prabhu  ;  Stefano Rausei  ;  Miran Rems  ;  Daniel Rios-Cruz  ;  Boris Sakakushev  ;  Maria Luisa Sánchez de Molina  ;  Charampolos Seretis  ;  Vishal Shelat  ;  Romeo Lages Simões  ;  Giovanni Sinibaldi  ;  Matej Skrovina  ;  Dmitry Smirnov  ;  Charalampos Spyropoulos  ;  Jaan Tepp  ;  Tugan Tezcaner  ;  Matti Tolonen  ;  Myftar Torba  ;  Jan Ulrych  ;  Mustafa Yener Uzunoglu  ;  David van Dellen  ;  Gabrielle H. van Ramshorst  ;  Giorgio Vasquez  ;  Aurélien Venara  ;  Andras Vereczkei  ;  Nereo Vettoretto  ;  Nutu Vlad  ;  Sanjay Kumar Yadav  ;  Tonguç Utku Yilmaz  ;  Kuo-Ching Yuan  ;  Sanoop Koshy Zachariah  ;  Maurice Zida  ;  Justas Zilinskas  ;  Luca Ansaloni 
Citation
 WORLD JOURNAL OF EMERGENCY SURGERY, Vol.10 : 61, 2015 
Journal Title
WORLD JOURNAL OF EMERGENCY SURGERY
Issue Date
2015
Keywords
Infections ; Intra-abdominal ; Sepsis ; Septic shock
Abstract
BACKGROUND: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression.

METHODS: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2 years (range 18-99) were enrolled in the WISS study.

RESULTS: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2 %, a specificity of 83.5 % and a positive likelihood ratio of 5.4.

CONCLUSIONS: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.
Files in This Item:
T201505096.pdf Download
DOI
10.1186/s13017-015-0055-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jae Gil(이재길) ORCID logo https://orcid.org/0000-0002-1148-8035
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157023
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