Cited 24 times in
Association between serum levels of adiponectin and polychlorinated biphenyls in Korean men and women
DC Field | Value | Language |
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dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2018-03-26T16:57:19Z | - |
dc.date.available | 2018-03-26T16:57:19Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1355-008X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157000 | - |
dc.description.abstract | Persistent organic pollutants (POPs) are endocrine-disrupting chemicals associated with metabolic syndrome and type 2 diabetes. In humans, little is known about their potential role on obesity. Adiponectin augments the effects of insulin on glucose homeostasis. The expression of adiponectin is reduced in obesity, insulin resistance, and type 2 diabetes. The aim of this study is to reveal whether accumulation of the POPs, especially polychlorinated biphenyls (PCBs), is associated with serum levels of adiponectin in Koreans. This cross-sectional study includes 98 Koreans (49 men and 49 women). Serum levels of marker PCBs (PCB 28, 52, 101, 138, 153, and 180) were measured by Agilent 7890GC-micro-ECD (Gas chromatography-micro-electron capture detector). Total adiponectin levels were quantified by enzyme-linked immunosorbent assay. We defined high (≥Median) and low (<Median) body mass index (BMI) groups by using median value of BMI (24.6 kg/m2 for men; 23.0 kg/m2 for women). PCB28, PCB138, and PCB153 were significantly negatively associated with adiponectin levels (β-coefficients=-0.00741 for PCB28; -0.00438 for PCB138; -0.00406 for PCB153). When we divided subjects by sex, PCB28 and PCB153 were inversely associated with adiponectin in women. In the high BMI group (≥Median), PCB153 showed the significant negative associations with adiponectin levels (P<0.05). However, these associations were not seen in the low BMI group. In conclusion, we found negative associations between PCBs and adiponectin. This cross-sectional study could provide support for the hypothesis that POPs exposure might contribute to type 2 diabetes as well as obesity. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Humana Press | - |
dc.relation.isPartOf | ENDOCRINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adiponectin/blood* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asian Continental Ancestry Group | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Environmental Pollutants/blood* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polychlorinated Biphenyls/blood* | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.title | Association between serum levels of adiponectin and polychlorinated biphenyls in Korean men and women | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health | - |
dc.contributor.department | Graduate School of Public Health | - |
dc.contributor.googleauthor | Jung-eun Lim | - |
dc.contributor.googleauthor | Sun Ha Jee | - |
dc.identifier.doi | 10.1007/s12020-014-0231-0 | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J00768 | - |
dc.identifier.eissn | 1559-0100 | - |
dc.identifier.pmid | 24664360 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12020-014-0231-0 | - |
dc.subject.keyword | Persistent organic pollutants (POPs) | - |
dc.subject.keyword | Polychlorinated biphenyls (PCBs) | - |
dc.subject.keyword | Adiponectin | - |
dc.subject.keyword | Insulin | - |
dc.subject.keyword | Body mass index | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Jee, Sun Ha | - |
dc.citation.volume | 48 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 211 | - |
dc.citation.endPage | 217 | - |
dc.identifier.bibliographicCitation | ENDOCRINE, Vol.48(1) : 211-217, 2015 | - |
dc.identifier.rimsid | 41309 | - |
dc.type.rims | ART | - |
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