Cited 21 times in
Prenatal Particulate Matter/Tobacco Smoke Increases Infants' Respiratory Infections: COCOA Study
DC Field | Value | Language |
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dc.contributor.author | 김경원 | - |
dc.date.accessioned | 2018-03-26T16:56:50Z | - |
dc.date.available | 2018-03-26T16:56:50Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156990 | - |
dc.description.abstract | PURPOSE: To investigate whether prenatal exposure to indoor fine particulate matter (PM₂.₅) and environmental tobacco smoke (ETS) affects susceptibility to respiratory tract infections (RTIs) in infancy, to compare their effects between prenatal and postnatal exposure, and to determine whether genetic factors modify these environmental effects. METHODS: The study population consisted of 307 birth cohort infants. A diagnosis of RTIs was based on parental report of a physician's diagnosis. Indoor PM₂.₅ and ETS levels were measured during pregnancy and infancy. TaqMan was used for genotyping of nuclear factor erythroid 2-related factor (Nrf2) (rs6726395), glutathione-S-transferase-pi (GSTP) 1 (rs1695), and glutathione-S-transferase-mu (GSTM) 1. Microarrays were used for genome-wide methylation analysis. RESULTS: Prenatal exposure to indoor PM₂.₅ increased the susceptibility of lower RTIs (LRTIs) in infancy (adjusted odds ratio [aOR]=2.11). In terms of combined exposure to both indoor PM₂.₅ and ETS, prenatal exposure to both pollutants increased susceptibility to LRTIs (aOR=6.56); however, this association was not found for postnatal exposure. The Nrf2 GG (aOR=23.69), GSTM1 null (aOR=8.18), and GSTP1 AG or GG (aOR=7.37) genotypes increased the combined LRTIs-promoting effects of prenatal exposure to the 2 indoor pollutants. Such effects of prenatal indoor PM₂.₅ and ETS exposure were not found for upper RTIs. CONCLUSIONS: Prenatal exposure to both indoor PM₂.₅ and ETS may increase susceptibility to LRTIs. This effect can be modified by polymorphisms in reactive oxygen species-related genes. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Korean Academy of Pediatric Allergy and Respiratory Disease | - |
dc.relation.isPartOf | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Prenatal Particulate Matter/Tobacco Smoke Increases Infants' Respiratory Infections: COCOA Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pediatrics | - |
dc.contributor.googleauthor | Song-I Yang | - |
dc.contributor.googleauthor | Byoung-Ju Kim | - |
dc.contributor.googleauthor | So-Yeon Lee | - |
dc.contributor.googleauthor | Hyo-Bin Kim | - |
dc.contributor.googleauthor | Cheol Min Lee | - |
dc.contributor.googleauthor | Jinho Yu | - |
dc.contributor.googleauthor | Mi-Jin Kang | - |
dc.contributor.googleauthor | Ho-Sung Yu | - |
dc.contributor.googleauthor | Eun Lee | - |
dc.contributor.googleauthor | Young-Ho Jung | - |
dc.contributor.googleauthor | Hyung Young Kim | - |
dc.contributor.googleauthor | Ju-Hee Seo | - |
dc.contributor.googleauthor | Ji-Won Kwon | - |
dc.contributor.googleauthor | Dae Jin Song | - |
dc.contributor.googleauthor | GwangCheon Jang | - |
dc.contributor.googleauthor | Woo-Kyung Kim | - |
dc.contributor.googleauthor | Jung Yeon Shim | - |
dc.contributor.googleauthor | Soo-Young Lee | - |
dc.contributor.googleauthor | Hyeon Jong Yang | - |
dc.contributor.googleauthor | Dong In Suh | - |
dc.contributor.googleauthor | Seo Ah Hong | - |
dc.contributor.googleauthor | Kil-Yong Choi | - |
dc.contributor.googleauthor | Youn Ho Shin | - |
dc.contributor.googleauthor | Kangmo Ahn | - |
dc.contributor.googleauthor | Kyung Won Kim | - |
dc.contributor.googleauthor | Eun-Jin Kim | - |
dc.contributor.googleauthor | Soo-Jong Hong | - |
dc.identifier.doi | 10.4168/aair.2015.7.6.573 | - |
dc.contributor.localId | A00303 | - |
dc.relation.journalcode | J00064 | - |
dc.identifier.eissn | 2092-7363 | - |
dc.identifier.pmid | 26333704 | - |
dc.subject.keyword | Prenatal exposure | - |
dc.subject.keyword | methylation | - |
dc.subject.keyword | particulate matter | - |
dc.subject.keyword | polymorphism | - |
dc.subject.keyword | respiratory tract infections | - |
dc.subject.keyword | tobacco smoke | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Won | - |
dc.citation.volume | 7 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 573 | - |
dc.citation.endPage | 582 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.7(6) : 573-582, 2015 | - |
dc.identifier.rimsid | 41299 | - |
dc.type.rims | ART | - |
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