0 796

Cited 12 times in

The Clinicopathologic Features and Prognostic Impact of ALK Positivity in Patients with Resected Gastric Cancer

DC Field Value Language
dc.contributor.author김혜련-
dc.contributor.author노성훈-
dc.contributor.author라선영-
dc.contributor.author전홍재-
dc.contributor.author정현철-
dc.contributor.author허수진-
dc.contributor.author이충근-
dc.date.accessioned2018-03-26T16:55:35Z-
dc.date.available2018-03-26T16:55:35Z-
dc.date.issued2015-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156970-
dc.description.abstractBACKGROUND: Rearrangement of ALK is an established driver aberration in lung cancer. Accordingly, this study attempted to determine the frequency and prognostic impact of ALK alterations in patients with surgically resected gastric cancer. METHODS: The study evaluated ALK alterations in whole tumor sections of 455 curatively resected gastric cancers via immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH). Any expression of ALK protein (1+, 2+, 3+ by IHC) was considered as evidence of ALK positivity (ALK+), and the relationship between ALK positivity and clinicopathologic parameters, including survival outcome, was analyzed. RESULTS: Of the 455 tumors, 38 (8.4 %) were ALK positive, as measured by IHC. Among the ALK+ patients, two displayed break-apart signals of 5 and 11 % on FISH, respectively. The ALK+ patients were younger (57 vs. 61 years; P = 0.02) and more likely to exhibit a signet ring cell component. Moreover, as ALK intensity measured by IHC increased, so did the proportion of signet ring cells in tumors (defined as ≥10 % of tumor cells; P = 0.02). In terms of survival outcome, the ALK+ patients displayed worse disease-free survival (DFS) and overall survival (OS) than the ALK- patients (P = 0.010 for DFS; P = 0.023 for OS). Multivariate analysis demonstrated that ALK+ gastric cancer patients were at an increased risk of recurrence and death after adjustment for sex, age, tumor location, stage, adjuvant chemotherapy, histology, and epidermal growth factor receptor 2 (HER2) positivity (P = 0.04 for DFS; P = 0.02 for OS). CONCLUSIONS: The findings showed ALK positivity to be an independent negative prognostic factor in surgically resected gastric cancers associated with signet ring cell histology.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/chemistry-
dc.subject.MESHAdenocarcinoma/genetics*-
dc.subject.MESHAdenocarcinoma/pathology*-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHEsophagogastric Junction*-
dc.subject.MESHFemale-
dc.subject.MESHGastrectomy-
dc.subject.MESHGene Rearrangement-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHReceptor Protein-Tyrosine Kinases/analysis-
dc.subject.MESHReceptor Protein-Tyrosine Kinases/genetics*-
dc.subject.MESHReceptor, ErbB-2/analysis-
dc.subject.MESHStomach Neoplasms/chemistry-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/pathology*-
dc.subject.MESHSurvival Rate-
dc.subject.MESHYoung Adult-
dc.titleThe Clinicopathologic Features and Prognostic Impact of ALK Positivity in Patients with Resected Gastric Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHong Jae Chon-
dc.contributor.googleauthorHye Ryun Kim-
dc.contributor.googleauthorEunah Shin-
dc.contributor.googleauthorChan Kim-
dc.contributor.googleauthorSu Jin Heo-
dc.contributor.googleauthorChoong-kun Lee-
dc.contributor.googleauthorJin Kyu Park-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorSun Young Rha-
dc.identifier.doi10.1245/s10434-015-4376-8-
dc.contributor.localIdA01166-
dc.contributor.localIdA01281-
dc.contributor.localIdA01316-
dc.contributor.localIdA03565-
dc.contributor.localIdA03773-
dc.contributor.localIdA04355-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid25707491-
dc.identifier.urlhttps://link.springer.com/article/10.1245/s10434-015-4376-8-
dc.subject.keywordGastric Cancer-
dc.subject.keywordOverall Survival-
dc.subject.keywordGastric Cancer Patient-
dc.subject.keywordSignet Ring Cell-
dc.subject.keywordAnaplastic Large Cell Lymphoma-
dc.contributor.alternativeNameKim, Hye Ryun-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameChon, Hong Jae-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameHeo, Su Jin-
dc.contributor.affiliatedAuthorKim, Hye Ryun-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorChon, Hong Jae-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorHeo, Su Jin-
dc.citation.volume22-
dc.citation.number12-
dc.citation.startPage3938-
dc.citation.endPage3945-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.22(12) : 3938-3945, 2015-
dc.identifier.rimsid41279-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.