Cited 11 times in
Prognostic Significance of AMP-Dependent Kinase Alpha Expression in Cervical Cancer
DC Field | Value | Language |
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dc.contributor.author | 김재훈 | - |
dc.contributor.author | 조한별 | - |
dc.date.accessioned | 2018-03-26T16:55:29Z | - |
dc.date.available | 2018-03-26T16:55:29Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1015-2008 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156968 | - |
dc.description.abstract | OBJECTIVES: Cervical cancer is one of the most common gynecological malignancies worldwide, and its association with the AMP-activated protein kinase (AMPK) is still unknown. We aimed to investigate the clinical correlation between AMPK expression and cervical cancer. METHODS: The expression of AMPKα1, AMPKα2 and phosphorylated AMPKα (p-AMPKα) was determined immunohistochemically in 524 formalin-fixed, paraffin-embedded malignant and premalignant cervical tissues. Subsequently, associations with clinicopathological characteristics and patient survival were assessed. RESULTS: AMPKα2 expression was observed in the cytoplasm and nucleus, while expression of AMPKα1 and p-AMPKα was mainly observed in the cytoplasm. p-AMPKα expression increased during the normal-to-tumor transition of cervical carcinoma (p < 0.001), but, once cancer developed, the expression of AMPKα2 and p-AMPKα decreased in large-sized tumors when compared to smaller tumors (36 vs. 68%, p = 0.004 and 39 vs. 64%, p = 0.029, respectively). Notably, AMPKα2 expression was significantly associated with better disease-free survival (HR 0.29, 95% CI 0.10-0.86, p = 0.026). CONCLUSION: The AMPKα2 isoform showed potential as a favorable prognostic marker in cervical cancer. Therefore, additional studies are necessary to further clarify the complex contribution of AMPK isoforms and of phosphorylation status to cervical cancer progression and prognosis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | S. Karger | - |
dc.relation.isPartOf | PATHOBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | AMP-Activated Protein Kinases/genetics* | - |
dc.subject.MESH | AMP-Activated Protein Kinases/metabolism* | - |
dc.subject.MESH | Biomarkers, Tumor | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Isoenzymes/genetics | - |
dc.subject.MESH | Isoenzymes/metabolism | - |
dc.subject.MESH | Phosphorylation | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Uterine Cervical Neoplasms/diagnosis | - |
dc.subject.MESH | Uterine Cervical Neoplasms/enzymology* | - |
dc.subject.MESH | Uterine Cervical Neoplasms/genetics* | - |
dc.title | Prognostic Significance of AMP-Dependent Kinase Alpha Expression in Cervical Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology | - |
dc.contributor.googleauthor | Chel Hun Choi | - |
dc.contributor.googleauthor | Joon-Yong Chung | - |
dc.contributor.googleauthor | Hanbyoul Cho | - |
dc.contributor.googleauthor | Haruhisa Kitano | - |
dc.contributor.googleauthor | Eileen Chang | - |
dc.contributor.googleauthor | Kris Ylaya | - |
dc.contributor.googleauthor | Eun Joo Chung | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.contributor.googleauthor | Stephen M. Hewitt | - |
dc.identifier.doi | 10.1159/000434726 | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A03921 | - |
dc.relation.journalcode | J02470 | - |
dc.identifier.eissn | 1423-0291 | - |
dc.identifier.pmid | 26337566 | - |
dc.identifier.url | https://www.karger.com/Article/Abstract/434726 | - |
dc.subject.keyword | AMP-activated protein kinase | - |
dc.subject.keyword | Carcinogenesis | - |
dc.subject.keyword | Cervical neoplasms | - |
dc.subject.keyword | Disease-free survival | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Cho, Han Byoul | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Cho, Han Byoul | - |
dc.citation.volume | 82 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 203 | - |
dc.citation.endPage | 211 | - |
dc.identifier.bibliographicCitation | PATHOBIOLOGY, Vol.82(5) : 203-211, 2015 | - |
dc.identifier.rimsid | 41277 | - |
dc.type.rims | ART | - |
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