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Peripheral NMDA receptors mediate antidromic nerve stimulation-induced tactile hypersensitivity in the rat

DC FieldValueLanguage
dc.contributor.author김동욱-
dc.contributor.author남택상-
dc.contributor.author임중우-
dc.contributor.author전재범-
dc.contributor.author정세정-
dc.date.accessioned2018-03-26T16:54:38Z-
dc.date.available2018-03-26T16:54:38Z-
dc.date.issued2015-
dc.identifier.issn0962-9351-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156950-
dc.description.abstractWe investigated the role of peripheral NMDA receptors (NMDARs) in antidromic nerve stimulation-induced tactile hypersensitivity outside the skin area innervated by stimulated nerve. Tetanic electrical stimulation (ES) of the decentralized L5 spinal nerve, which induced enlargement of plasma extravasation, resulted in tactile hypersensitivity in the L4 plantar dermatome of the hind-paw. When intraplantar (i.pl.) injection was administered into the L4 dermatome before ES, NMDAR and group-I metabotropic Glu receptor (mGluR) antagonists and group-II mGluR agonist but not AMPA/kainate receptor antagonist prevented ES-induced hypersensitivity. I.pl. injection of PKA or PKC inhibitors also prevented ES-induced hypersensitivity. When the same injections were administered after establishment of ES-induced hypersensitivity, hypersensitivity was partially reduced by NMDAR antagonist only. In naïve animals, i.pl. Glu injection into the L4 dermatome induced tactile hypersensitivity, which was blocked by NMDAR antagonist and PKA and PKC inhibitors. These results suggest that the peripheral release of Glu, induced by antidromic nerve stimulation, leads to the expansion of tactile hypersensitive skin probably via nociceptor sensitization spread due to the diffusion of Glu into the skin near the release site. In addition, intracellular PKA- and PKC-dependent mechanisms mediated mainly by NMDAR activation are involved in Glu-induced nociceptor sensitization and subsequent hypersensitivity.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherHindawi Pub. Corp.-
dc.relation.isPartOfMEDIATORS OF INFLAMMATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCyclic AMP-Dependent Protein Kinases/physiology-
dc.subject.MESHDizocilpine Maleate/pharmacology-
dc.subject.MESHElectric Stimulation-
dc.subject.MESHGlutamic Acid/physiology-
dc.subject.MESHHyperalgesia/etiology*-
dc.subject.MESHIsoquinolines/pharmacology-
dc.subject.MESHMale-
dc.subject.MESHProtein Kinase C/physiology-
dc.subject.MESHQuinoxalines/pharmacology-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptors, N-Methyl-D-Aspartate/physiology*-
dc.subject.MESHSulfonamides/pharmacology-
dc.subject.MESHTibial Nerve/physiology*-
dc.titlePeripheral NMDA receptors mediate antidromic nerve stimulation-induced tactile hypersensitivity in the rat-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Physiology-
dc.contributor.googleauthorJun Ho Jang-
dc.contributor.googleauthorTaick Sang Nam-
dc.contributor.googleauthorJaebeom Jun-
dc.contributor.googleauthorSe Jung Jung-
dc.contributor.googleauthorDong-Wook Kim-
dc.contributor.googleauthorJoong Woo Leem-
dc.identifier.doi10.1155/2015/793624-
dc.contributor.localIdA01271-
dc.contributor.localIdA03409-
dc.contributor.localIdA04795-
dc.contributor.localIdA03629-
dc.contributor.localIdA00406-
dc.relation.journalcodeJ02194-
dc.identifier.eissn1466-1861-
dc.identifier.pmid26770021-
dc.contributor.alternativeNameKim, Dong Wook-
dc.contributor.alternativeNameNam, Taick Sang-
dc.contributor.alternativeNameLeem, Joong Woo-
dc.contributor.alternativeNameJun, Jae Beom-
dc.contributor.alternativeNameJung, Se Jung-
dc.contributor.affiliatedAuthorNam, Taick Sang-
dc.contributor.affiliatedAuthorLeem, Joong Woo-
dc.contributor.affiliatedAuthorJun, Jae Beom-
dc.contributor.affiliatedAuthorJung, Se Jung-
dc.contributor.affiliatedAuthorKim, Dong Wook-
dc.citation.volume2015-
dc.citation.startPage793624-
dc.identifier.bibliographicCitationMEDIATORS OF INFLAMMATION, Vol.2015 : 793624, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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