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Glycated Albumin Levels in Patients with Type 2 Diabetes Increase Relative to HbA1c with Time

DC Field Value Language
dc.contributor.author강은석-
dc.contributor.author김광준-
dc.contributor.author김소라-
dc.contributor.author이병완-
dc.contributor.author이용호-
dc.contributor.author이현철-
dc.contributor.author차봉수-
dc.date.accessioned2018-03-26T16:54:32Z-
dc.date.available2018-03-26T16:54:32Z-
dc.date.issued2015-
dc.identifier.issn2314-6133-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156949-
dc.description.abstractWe recently reported that glycated albumin (GA) is increased in subjects with longer duration of diabetes and with decreased insulin secretory function. Based on this, we investigated whether GA increases with time relative to glycated hemoglobin (HbA1c) and the association between GA and beta-cell function. We analyzed 340 type 2 diabetes patients whose serum GA and HbA1c levels had been repeatedly measured over 4 years. We assessed the pattern of changes with time in glycemic indices (GA, HbA1c, and GA/HbA1c ratio) and their relationship with beta-cell function. In all patients, glycemic indices decreased and maintained low levels around 15 and 27 months. However, from 39 months to 51 months, GA significantly increased but HbA1c tended to increase without statistical significance. We defined ΔGA/HbA1c as the difference between the nadir point (at 15 to 27 months) and the end point (at 39 to 51 months) and found that ΔGA/HbA1c was positively correlated with diabetes duration and negatively related to beta-cell function. In multivariable linear regression analyses, ΔGA/HbA1c was independently associated with diabetes duration. In conclusion, this study demonstrated that serum GA levels increase relative to HbA1c levels with time.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherHindawi Pub. Co.-
dc.relation.isPartOfBIOMED RESEARCH INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHDiabetes Mellitus, Type 2/blood*-
dc.subject.MESHDiabetes Mellitus, Type 2/pathology-
dc.subject.MESHFemale-
dc.subject.MESHGlycated Hemoglobin A/metabolism*-
dc.subject.MESHHumans-
dc.subject.MESHInsulin/metabolism*-
dc.subject.MESHInsulin-Secreting Cells/metabolism-
dc.subject.MESHInsulin-Secreting Cells/pathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHSerum Albumin/metabolism*-
dc.titleGlycated Albumin Levels in Patients with Type 2 Diabetes Increase Relative to HbA1c with Time-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHye-jin Yoon-
dc.contributor.googleauthorYong-ho Lee-
dc.contributor.googleauthorKwang Joon Kim-
dc.contributor.googleauthorSo Ra Kim-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorBong-Soo Cha-
dc.contributor.googleauthorHyun Chul Lee-
dc.contributor.googleauthorByung-Wan Lee-
dc.identifier.doi10.1155/2015/576306-
dc.contributor.localIdA00068-
dc.contributor.localIdA00317-
dc.contributor.localIdA00612-
dc.contributor.localIdA02796-
dc.contributor.localIdA02989-
dc.contributor.localIdA03301-
dc.contributor.localIdA03996-
dc.relation.journalcodeJ00315-
dc.identifier.eissn2314-6141-
dc.identifier.pmid26484352-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Kwang Joon-
dc.contributor.alternativeNameKim, So Ra-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.contributor.affiliatedAuthorKim, So Ra-
dc.contributor.affiliatedAuthorLee, Byung Wan-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.citation.volume2015-
dc.citation.startPage576306-
dc.identifier.bibliographicCitationBIOMED RESEARCH INTERNATIONAL, Vol.2015 : 576306, 2015-
dc.identifier.rimsid41258-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Hospital Medicine (입원의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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