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Glycated Albumin Levels in Patients with Type 2 Diabetes Increase Relative to HbA1c with Time

 Hye-jin Yoon  ;  Yong-ho Lee  ;  Kwang Joon Kim  ;  So Ra Kim  ;  Eun Seok Kang  ;  Bong-Soo Cha  ;  Hyun Chul Lee  ;  Byung-Wan Lee 
 BIOMED RESEARCH INTERNATIONAL, Vol.2015 : 576306, 2015 
Journal Title
Issue Date
Adult ; Aged ; Diabetes Mellitus, Type 2/blood* ; Diabetes Mellitus, Type 2/pathology ; Female ; Glycated Hemoglobin A/metabolism* ; Humans ; Insulin/metabolism* ; Insulin-Secreting Cells/metabolism ; Insulin-Secreting Cells/pathology ; Male ; Middle Aged ; Serum Albumin/metabolism*
We recently reported that glycated albumin (GA) is increased in subjects with longer duration of diabetes and with decreased insulin secretory function. Based on this, we investigated whether GA increases with time relative to glycated hemoglobin (HbA1c) and the association between GA and beta-cell function. We analyzed 340 type 2 diabetes patients whose serum GA and HbA1c levels had been repeatedly measured over 4 years. We assessed the pattern of changes with time in glycemic indices (GA, HbA1c, and GA/HbA1c ratio) and their relationship with beta-cell function. In all patients, glycemic indices decreased and maintained low levels around 15 and 27 months. However, from 39 months to 51 months, GA significantly increased but HbA1c tended to increase without statistical significance. We defined ΔGA/HbA1c as the difference between the nadir point (at 15 to 27 months) and the end point (at 39 to 51 months) and found that ΔGA/HbA1c was positively correlated with diabetes duration and negatively related to beta-cell function. In multivariable linear regression analyses, ΔGA/HbA1c was independently associated with diabetes duration. In conclusion, this study demonstrated that serum GA levels increase relative to HbA1c levels with time.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Hospital Medicine (입원의학과) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Kim, So Ra(김소라)
Lee, Byung Wan(이병완) ORCID logo https://orcid.org/0000-0002-9899-4992
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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