Cited 9 times in
A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression
DC Field | Value | Language |
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dc.contributor.author | 김현석 | - |
dc.date.accessioned | 2018-03-26T16:54:21Z | - |
dc.date.available | 2018-03-26T16:54:21Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156946 | - |
dc.description.abstract | Large-scale molecular annotation of epithelial ovarian cancer (EOC) indicates remarkable heterogeneity in the etiology of that disease. This diversity presents a significant obstacle against intervention target discovery. However, inactivation of miRNA biogenesis is commonly associated with advanced disease. Thus, restoration of miRNA activity may represent a common vulnerability among diverse EOC oncogenotypes. To test this, we employed genome-scale, gain-of-function, miRNA mimic toxicity screens in a large, diverse spectrum of EOC cell lines. We found that all cell lines responded to at least some miRNA mimics, but that the nature of the miRNA mimics provoking a response was highly selective within the panel. These selective toxicity profiles were leveraged to define modes of action and molecular response indicators for miRNA mimics with tumor-suppressive characteristics in vivo. A mechanistic principle emerging from this analysis was sensitivity of EOC to miRNA-mediated release of cell fate specification programs, loss of which may be a prerequisite for development of this disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Wiley Blackwell | - |
dc.relation.isPartOf | MOLECULAR SYSTEMS BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biomimetic Materials/administration & dosage* | - |
dc.subject.MESH | Biomimetic Materials/pharmacology | - |
dc.subject.MESH | Cell Differentiation/drug effects | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Down-Regulation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic/drug effects | - |
dc.subject.MESH | Genome-Wide Association Study | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | MicroRNAs/genetics* | - |
dc.subject.MESH | Neoplasms, Glandular and Epithelial/drug therapy* | - |
dc.subject.MESH | Neoplasms, Glandular and Epithelial/genetics* | - |
dc.subject.MESH | Ovarian Neoplasms/drug therapy* | - |
dc.subject.MESH | Ovarian Neoplasms/genetics* | - |
dc.subject.MESH | Xenograft Model Antitumor Assays | - |
dc.title | A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | Benjamin B Shields | - |
dc.contributor.googleauthor | Chad V Pecot | - |
dc.contributor.googleauthor | Hua Gao | - |
dc.contributor.googleauthor | Elizabeth McMillan | - |
dc.contributor.googleauthor | Malia Potts | - |
dc.contributor.googleauthor | Christa Nagel | - |
dc.contributor.googleauthor | Scott Purinton | - |
dc.contributor.googleauthor | Ying Wang | - |
dc.contributor.googleauthor | Cristina Ivan | - |
dc.contributor.googleauthor | Hyun Seok Kim | - |
dc.contributor.googleauthor | Robert J Borkowski | - |
dc.contributor.googleauthor | Shaheen Khan | - |
dc.contributor.googleauthor | Cristian Rodriguez-Aguayo | - |
dc.contributor.googleauthor | Gabriel Lopez-Berestein | - |
dc.contributor.googleauthor | Jayanthi Lea | - |
dc.contributor.googleauthor | Adi Gazdar | - |
dc.contributor.googleauthor | Keith A Baggerly | - |
dc.contributor.googleauthor | Anil K Sood | - |
dc.contributor.googleauthor | Michael A White | - |
dc.identifier.doi | 10.15252/msb.20156308 | - |
dc.contributor.localId | A01111 | - |
dc.relation.journalcode | J02933 | - |
dc.identifier.eissn | 1744-4292 | - |
dc.identifier.pmid | 26655797 | - |
dc.subject.keyword | cancer | - |
dc.subject.keyword | cancer genetics | - |
dc.subject.keyword | miRNA | - |
dc.subject.keyword | microRNA | - |
dc.subject.keyword | ovarian cancer | - |
dc.contributor.alternativeName | Kim, Hyun Seok | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Seok | - |
dc.citation.volume | 11 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 842 | - |
dc.identifier.bibliographicCitation | MOLECULAR SYSTEMS BIOLOGY, Vol.11(12) : 842, 2015 | - |
dc.identifier.rimsid | 41255 | - |
dc.type.rims | ART | - |
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