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A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression

DC FieldValueLanguage
dc.contributor.author김현석-
dc.date.accessioned2018-03-26T16:54:21Z-
dc.date.available2018-03-26T16:54:21Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156946-
dc.description.abstractLarge-scale molecular annotation of epithelial ovarian cancer (EOC) indicates remarkable heterogeneity in the etiology of that disease. This diversity presents a significant obstacle against intervention target discovery. However, inactivation of miRNA biogenesis is commonly associated with advanced disease. Thus, restoration of miRNA activity may represent a common vulnerability among diverse EOC oncogenotypes. To test this, we employed genome-scale, gain-of-function, miRNA mimic toxicity screens in a large, diverse spectrum of EOC cell lines. We found that all cell lines responded to at least some miRNA mimics, but that the nature of the miRNA mimics provoking a response was highly selective within the panel. These selective toxicity profiles were leveraged to define modes of action and molecular response indicators for miRNA mimics with tumor-suppressive characteristics in vivo. A mechanistic principle emerging from this analysis was sensitivity of EOC to miRNA-mediated release of cell fate specification programs, loss of which may be a prerequisite for development of this disease.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWiley Blackwell-
dc.relation.isPartOfMOLECULAR SYSTEMS BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBiomimetic Materials/administration & dosage*-
dc.subject.MESHBiomimetic Materials/pharmacology-
dc.subject.MESHCell Differentiation/drug effects-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Proliferation/drug effects-
dc.subject.MESHCell Survival/drug effects-
dc.subject.MESHDown-Regulation-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic/drug effects-
dc.subject.MESHGenome-Wide Association Study-
dc.subject.MESHHumans-
dc.subject.MESHMice-
dc.subject.MESHMicroRNAs/genetics*-
dc.subject.MESHNeoplasms, Glandular and Epithelial/drug therapy*-
dc.subject.MESHNeoplasms, Glandular and Epithelial/genetics*-
dc.subject.MESHOvarian Neoplasms/drug therapy*-
dc.subject.MESHOvarian Neoplasms/genetics*-
dc.subject.MESHXenograft Model Antitumor Assays-
dc.titleA genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorBenjamin B Shields-
dc.contributor.googleauthorChad V Pecot-
dc.contributor.googleauthorHua Gao-
dc.contributor.googleauthorElizabeth McMillan-
dc.contributor.googleauthorMalia Potts-
dc.contributor.googleauthorChrista Nagel-
dc.contributor.googleauthorScott Purinton-
dc.contributor.googleauthorYing Wang-
dc.contributor.googleauthorCristina Ivan-
dc.contributor.googleauthorHyun Seok Kim-
dc.contributor.googleauthorRobert J Borkowski-
dc.contributor.googleauthorShaheen Khan-
dc.contributor.googleauthorCristian Rodriguez-Aguayo-
dc.contributor.googleauthorGabriel Lopez-Berestein-
dc.contributor.googleauthorJayanthi Lea-
dc.contributor.googleauthorAdi Gazdar-
dc.contributor.googleauthorKeith A Baggerly-
dc.contributor.googleauthorAnil K Sood-
dc.contributor.googleauthorMichael A White-
dc.identifier.doiX-
dc.contributor.localIdA01111-
dc.relation.journalcodeJ02933-
dc.identifier.eissn1744-4292-
dc.identifier.pmid26655797-
dc.subject.keywordcancer-
dc.subject.keywordcancer genetics-
dc.subject.keywordmiRNA-
dc.subject.keywordmicroRNA-
dc.subject.keywordovarian cancer-
dc.contributor.alternativeNameKim, Hyun Seok-
dc.contributor.affiliatedAuthorKim, Hyun Seok-
dc.citation.volume11-
dc.citation.number12-
dc.citation.startPage842-
dc.identifier.bibliographicCitationMOLECULAR SYSTEMS BIOLOGY, Vol.11(12) : 842, 2015-
dc.identifier.rimsid41255-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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