Cited 61 times in
Possible Role of Phthalate in the Pathogenesis of Endometriosis: In Vitro, Animal, and Human Data
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조시현 | - |
dc.date.accessioned | 2018-03-26T16:53:55Z | - |
dc.date.available | 2018-03-26T16:53:55Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156936 | - |
dc.description.abstract | CONTEXT: Although phthalates were shown to have several negative effects on reproductive function in animals, its role in the pathogenesis of endometriosis remains to be elucidated. OBJECTIVE: We aimed to investigate the in vitro and in vivo effects of di-(2-ethylhexyl)-phthalate (DEHP) and to compare the urinary levels of several phthalate metabolites between women with and without endometriosis. DESIGN: For experimental studies, we used endometrial cell culture and nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse models. We also performed a prospective case-control study for human sample analyses. SETTING: The study was conducted at an academic center. MAIN OUTCOME MEASURES: The activities of matrix metalloproteinase (MMP)-2 and 9, cellular invasiveness, phosphorylation of extracellular signal-regulated kinase (Erk), and expression of p21-activated kinase 4 were analyzed in endometrial cells treated with DEHP. The implant size was compared between NOD/SCID mice fed with and without DEHP. Urinary concentrations of several phthalate metabolites were compared between women with and without endometriosis. RESULTS: In vitro treatment of endometrial cells with DEHP led to significant increases of MMP-2 and 9 activities, cellular invasiveness, Erk phosphorylation, and p21-activated kinase 4 expression. The size of the endometrial implant was significantly larger in the NOD/SCID mice fed with DEHP compared with those fed with vehicle. The urinary concentration of mono (2-ethyl-5-hydroxyhexyl) phthalate, mono (2-ethyl-5-oxohexyl) phthalate, and mono (2-ethyl-5-carboxyphentyl) phthalate were significantly higher in women with endometriosis compared with controls. CONCLUSION: These findings strongly suggest that exposure to phthalate may lead to establishment of endometriosis by enhancing invasive and proliferative activities of endometrial cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Endocrine Society | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Diethylhexyl Phthalate/toxicity* | - |
dc.subject.MESH | Endometriosis/chemically induced* | - |
dc.subject.MESH | Endometriosis/epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | MAP Kinase Signaling System | - |
dc.subject.MESH | Matrix Metalloproteinase 2/metabolism | - |
dc.subject.MESH | Matrix Metalloproteinase 9/metabolism | - |
dc.subject.MESH | Mice, Inbred NOD | - |
dc.subject.MESH | Mice, SCID | - |
dc.subject.MESH | Phthalic Acids/urine | - |
dc.subject.MESH | Plasticizers/toxicity* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Stromal Cells/metabolism | - |
dc.subject.MESH | p21-Activated Kinases/genetics | - |
dc.subject.MESH | p21-Activated Kinases/metabolism | - |
dc.title | Possible Role of Phthalate in the Pathogenesis of Endometriosis: In Vitro, Animal, and Human Data | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology | - |
dc.contributor.googleauthor | Sung Hoon Kim | - |
dc.contributor.googleauthor | SiHyun Cho | - |
dc.contributor.googleauthor | Hyo Jin Ihm | - |
dc.contributor.googleauthor | Young Sang Oh | - |
dc.contributor.googleauthor | Seung-Ho Heo | - |
dc.contributor.googleauthor | Sail Chun | - |
dc.contributor.googleauthor | Hosub Im | - |
dc.contributor.googleauthor | Hee Dong Chae | - |
dc.contributor.googleauthor | Chung-Hoon Kim | - |
dc.contributor.googleauthor | Byung Moon Kang | - |
dc.identifier.doi | 10.1210/jc.2015-2478 | - |
dc.contributor.localId | A03846 | - |
dc.relation.journalcode | J01318 | - |
dc.identifier.eissn | 1945-7197 | - |
dc.identifier.pmid | 26439087 | - |
dc.identifier.url | https://academic.oup.com/jcem/article/100/12/E1502/2536248 | - |
dc.contributor.alternativeName | Cho, Si Hyun | - |
dc.contributor.affiliatedAuthor | Cho, Si Hyun | - |
dc.citation.volume | 100 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | E1502 | - |
dc.citation.endPage | E1511 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.100(12) : E1502-E1511, 2015 | - |
dc.identifier.rimsid | 41245 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.