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Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study

DC FieldValueLanguage
dc.contributor.author정병하-
dc.date.accessioned2018-03-26T16:53:35Z-
dc.date.available2018-03-26T16:53:35Z-
dc.date.issued2015-
dc.identifier.issn2093-4777-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156926-
dc.description.abstractPURPOSE: In this study, we compared the treatment outcomes for an α-blocker between 2 groups of men, one with high sympathetic activity (HSA) and another with low sympathetic activity (LSA) or normal sympathetic activity. METHODS: A total of 159 men (≥50 years of age) with lower urinary tract symptoms resulting from benign prostatic hyperplasia were analyzed. We assigned patients to groups according to their sympathetic activity, which was evaluated by heart ratevariability measurements. HSA was defined as a low frequency/high frequency ratio greater than 1.6. All patients received 10mg of alfuzosin once a day for 12 weeks. The primary end point was a change in the total International Prostate SymptomScore (IPSS) at 12 weeks from baseline. RESULTS: Sixty-seven men were assigned to the HSA group and 92 men were assigned to the LSA group. The baseline characteristics were not significantly different between the 2 groups, and the response to alfuzosin was good in both groups. Themean total IPSS change was not different between the groups. Both groups were not significantly different with respect to the changes in maximal flow rate, IPSS voiding or storage symptom subscores, quality of life, and rates of adverse drug events. TheHSA group showed a similar willingness to continue treatment compared to the LSA group, although their treatment satisfaction rating was lower. CONCLUSIONS: The therapeutic effects of alfuzosin did not differ in regards to the differences in sympathetic activity, but treatment satisfaction ratings were lower in the HSA group.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Continence Society-
dc.relation.isPartOfINTERNATIONAL NEUROUROLOGY JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAlpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Urology-
dc.contributor.googleauthorSung Gon Park-
dc.contributor.googleauthorByung Ha Chung-
dc.contributor.googleauthorSung Won Lee-
dc.contributor.googleauthorJong Kwan Park-
dc.contributor.googleauthorKwangsung Park-
dc.contributor.googleauthorJun Cheon-
dc.contributor.googleauthorKyung Seop Lee-
dc.contributor.googleauthorHyung-Jee Kim-
dc.contributor.googleauthorDo-Hwan Seong-
dc.contributor.googleauthorSeung-June Oh-
dc.contributor.googleauthorSae Woong Kim-
dc.contributor.googleauthorJi Youl Lee-
dc.contributor.googleauthorSeol Ho Choo-
dc.contributor.googleauthorJong Bo Choi-
dc.identifier.doi10.5213/inj.2015.19.2.107-
dc.contributor.localIdA03607-
dc.relation.journalcodeJ01171-
dc.identifier.eissn2093-6931-
dc.identifier.pmid26126440-
dc.subject.keywordHeart Rate-
dc.subject.keywordLower Urinary Tract Symptoms-
dc.subject.keywordProstatic Hyperplasia-
dc.subject.keywordSympathetic Nervous System-
dc.contributor.alternativeNameChung, Byung Ha-
dc.contributor.affiliatedAuthorChung, Byung Ha-
dc.citation.volume19-
dc.citation.number2-
dc.citation.startPage107-
dc.citation.endPage112-
dc.identifier.bibliographicCitationINTERNATIONAL NEUROUROLOGY JOURNAL, Vol.19(2) : 107-112, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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